Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow
Summary: In many organs, stem cell function depends on communication with their niche partners. Cranial sensory neurons develop in close proximity to blood vessels; however, whether vasculature is an integral component of their niches is yet unknown. Here, two separate roles for vasculature in crani...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-07-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124720308846 |
| _version_ | 1818579486548951040 |
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| author | Laura Taberner Aitor Bañón Berta Alsina |
| author_facet | Laura Taberner Aitor Bañón Berta Alsina |
| author_sort | Laura Taberner |
| collection | DOAJ |
| description | Summary: In many organs, stem cell function depends on communication with their niche partners. Cranial sensory neurons develop in close proximity to blood vessels; however, whether vasculature is an integral component of their niches is yet unknown. Here, two separate roles for vasculature in cranial sensory neurogenesis in zebrafish are uncovered. The first involves precise spatiotemporal endothelial-neuroblast cytoneme contacts and Dll4-Notch signaling to restrain neuroblast proliferation. The second, instead, requires blood flow to trigger a transcriptional response that modifies neuroblast metabolic status and induces sensory neuron differentiation. In contrast, no role of sensory neurogenesis in vascular development is found, suggesting unidirectional signaling from vasculature to sensory neuroblasts. Altogether, we demonstrate that the cranial vasculature constitutes a niche component of the sensory ganglia that regulates the pace of their growth and differentiation dynamics. |
| first_indexed | 2024-12-16T07:02:28Z |
| format | Article |
| id | doaj.art-48fae34aa7cb41c295f6c665586f913e |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-16T07:02:28Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-48fae34aa7cb41c295f6c665586f913e2022-12-21T22:40:07ZengElsevierCell Reports2211-12472020-07-01322107903Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood FlowLaura Taberner0Aitor Bañón1Berta Alsina2Developmental Biology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra—Parc de Recerca Biomèdica de Barcelona, Dr. Aiguader 88, 08003 Barcelona, SpainDevelopmental Biology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra—Parc de Recerca Biomèdica de Barcelona, Dr. Aiguader 88, 08003 Barcelona, SpainDevelopmental Biology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra—Parc de Recerca Biomèdica de Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain; Corresponding authorSummary: In many organs, stem cell function depends on communication with their niche partners. Cranial sensory neurons develop in close proximity to blood vessels; however, whether vasculature is an integral component of their niches is yet unknown. Here, two separate roles for vasculature in cranial sensory neurogenesis in zebrafish are uncovered. The first involves precise spatiotemporal endothelial-neuroblast cytoneme contacts and Dll4-Notch signaling to restrain neuroblast proliferation. The second, instead, requires blood flow to trigger a transcriptional response that modifies neuroblast metabolic status and induces sensory neuron differentiation. In contrast, no role of sensory neurogenesis in vascular development is found, suggesting unidirectional signaling from vasculature to sensory neuroblasts. Altogether, we demonstrate that the cranial vasculature constitutes a niche component of the sensory ganglia that regulates the pace of their growth and differentiation dynamics.http://www.sciencedirect.com/science/article/pii/S2211124720308846sensory neuronsvascularnichecytonemeDll4/Notchblood flow |
| spellingShingle | Laura Taberner Aitor Bañón Berta Alsina Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow Cell Reports sensory neurons vascular niche cytoneme Dll4/Notch blood flow |
| title | Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow |
| title_full | Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow |
| title_fullStr | Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow |
| title_full_unstemmed | Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow |
| title_short | Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow |
| title_sort | sensory neuroblast quiescence depends on vascular cytoneme contacts and sensory neuronal differentiation requires initiation of blood flow |
| topic | sensory neurons vascular niche cytoneme Dll4/Notch blood flow |
| url | http://www.sciencedirect.com/science/article/pii/S2211124720308846 |
| work_keys_str_mv | AT laurataberner sensoryneuroblastquiescencedependsonvascularcytonemecontactsandsensoryneuronaldifferentiationrequiresinitiationofbloodflow AT aitorbanon sensoryneuroblastquiescencedependsonvascularcytonemecontactsandsensoryneuronaldifferentiationrequiresinitiationofbloodflow AT bertaalsina sensoryneuroblastquiescencedependsonvascularcytonemecontactsandsensoryneuronaldifferentiationrequiresinitiationofbloodflow |