Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines
Oncolytic viruses (OVs) are a form of immunotherapy that release tumor antigens in the context of highly immunogenic viral signals following tumor-targeted infection and destruction. Emerging preclinical and clinical evidence suggests that this in situ vaccine effect is critical for successful viro-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/11/5/434 |
| _version_ | 1818163144034353152 |
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| author | Seyedeh Raheleh Niavarani Christine Lawson Lee-Hwa Tai |
| author_facet | Seyedeh Raheleh Niavarani Christine Lawson Lee-Hwa Tai |
| author_sort | Seyedeh Raheleh Niavarani |
| collection | DOAJ |
| description | Oncolytic viruses (OVs) are a form of immunotherapy that release tumor antigens in the context of highly immunogenic viral signals following tumor-targeted infection and destruction. Emerging preclinical and clinical evidence suggests that this in situ vaccine effect is critical for successful viro-immunotherapy. In this review, we discuss the application of OV as an infected cell vaccine (ICV) as one method of enhancing the potency and breadth of anti-tumoral immunity. We focus on understanding and manipulating the critical role of natural killer (NK) cells and their interactions with other immune cells to promote a clinical outcome. With a synergistic tumor killing and immune activating mechanism, ICVs represent a valuable new addition to the cancer fighting toolbox with the potential to treat malignant disease. |
| first_indexed | 2024-12-11T16:44:53Z |
| format | Article |
| id | doaj.art-48fb04f85be64609b052eb929d652ec2 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-11T16:44:53Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-48fb04f85be64609b052eb929d652ec22022-12-22T00:58:14ZengMDPI AGViruses1999-49152019-05-0111543410.3390/v11050434v11050434Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell VaccinesSeyedeh Raheleh Niavarani0Christine Lawson1Lee-Hwa Tai2Department of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke QC J1E 4K8, CanadaDepartment of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke QC J1E 4K8, CanadaDepartment of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke QC J1E 4K8, CanadaOncolytic viruses (OVs) are a form of immunotherapy that release tumor antigens in the context of highly immunogenic viral signals following tumor-targeted infection and destruction. Emerging preclinical and clinical evidence suggests that this in situ vaccine effect is critical for successful viro-immunotherapy. In this review, we discuss the application of OV as an infected cell vaccine (ICV) as one method of enhancing the potency and breadth of anti-tumoral immunity. We focus on understanding and manipulating the critical role of natural killer (NK) cells and their interactions with other immune cells to promote a clinical outcome. With a synergistic tumor killing and immune activating mechanism, ICVs represent a valuable new addition to the cancer fighting toolbox with the potential to treat malignant disease.https://www.mdpi.com/1999-4915/11/5/434immunotherapyoncolytic virusautologous cancer vaccinesinfected cell vaccinesnatural killer cellsimmunomonitoring |
| spellingShingle | Seyedeh Raheleh Niavarani Christine Lawson Lee-Hwa Tai Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines Viruses immunotherapy oncolytic virus autologous cancer vaccines infected cell vaccines natural killer cells immunomonitoring |
| title | Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines |
| title_full | Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines |
| title_fullStr | Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines |
| title_full_unstemmed | Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines |
| title_short | Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines |
| title_sort | treatment of metastatic disease through natural killer cell modulation by infected cell vaccines |
| topic | immunotherapy oncolytic virus autologous cancer vaccines infected cell vaccines natural killer cells immunomonitoring |
| url | https://www.mdpi.com/1999-4915/11/5/434 |
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