Recent advances in the management of Wilms' tumor [version 1; referees: 2 approved]
The objective of this article is to present an overview of recent trends in the management of Wilms’ tumor. With improved survival rates in the past few decades, critical long-term adverse therapy effects (such as renal insufficiency, secondary malignancies, and heart failure) and prevention measure...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-05-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-670/v1 |
| _version_ | 1818542596586209280 |
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| author | Roberto I. Lopes Armando Lorenzo |
| author_facet | Roberto I. Lopes Armando Lorenzo |
| author_sort | Roberto I. Lopes |
| collection | DOAJ |
| description | The objective of this article is to present an overview of recent trends in the management of Wilms’ tumor. With improved survival rates in the past few decades, critical long-term adverse therapy effects (such as renal insufficiency, secondary malignancies, and heart failure) and prevention measures (i.e. nephron-sparing surgery and minimizing the use of radiotherapy) have gained worldwide attention. Specific disease biomarkers that could help stratify high-risk from low-risk patients, and therefore fine-tune management, are in great demand. Ultimately, we aim to enhance clinical outcomes and maintain or improve current survival rates while avoiding undesirable treatment side effects and minimizing the exposure and intensity of chemotherapy and radiotherapy. |
| first_indexed | 2024-12-11T22:24:11Z |
| format | Article |
| id | doaj.art-48fe0f8066d64987b42fcb350acad6b8 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T22:24:11Z |
| publishDate | 2017-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-48fe0f8066d64987b42fcb350acad6b82022-12-22T00:48:20ZengF1000 Research LtdF1000Research2046-14022017-05-01610.12688/f1000research.10760.111601Recent advances in the management of Wilms' tumor [version 1; referees: 2 approved]Roberto I. Lopes0Armando Lorenzo1Department of Surgery, University of Toronto, Toronto, ON, CanadaDepartment of Surgery, University of Toronto, Toronto, ON, CanadaThe objective of this article is to present an overview of recent trends in the management of Wilms’ tumor. With improved survival rates in the past few decades, critical long-term adverse therapy effects (such as renal insufficiency, secondary malignancies, and heart failure) and prevention measures (i.e. nephron-sparing surgery and minimizing the use of radiotherapy) have gained worldwide attention. Specific disease biomarkers that could help stratify high-risk from low-risk patients, and therefore fine-tune management, are in great demand. Ultimately, we aim to enhance clinical outcomes and maintain or improve current survival rates while avoiding undesirable treatment side effects and minimizing the exposure and intensity of chemotherapy and radiotherapy.https://f1000research.com/articles/6-670/v1Cancer TherapeuticsCell Growth & DivisionControl of Gene ExpressionGenitourinary CancersMedical GeneticsPediatric Oncology |
| spellingShingle | Roberto I. Lopes Armando Lorenzo Recent advances in the management of Wilms' tumor [version 1; referees: 2 approved] F1000Research Cancer Therapeutics Cell Growth & Division Control of Gene Expression Genitourinary Cancers Medical Genetics Pediatric Oncology |
| title | Recent advances in the management of Wilms' tumor [version 1; referees: 2 approved] |
| title_full | Recent advances in the management of Wilms' tumor [version 1; referees: 2 approved] |
| title_fullStr | Recent advances in the management of Wilms' tumor [version 1; referees: 2 approved] |
| title_full_unstemmed | Recent advances in the management of Wilms' tumor [version 1; referees: 2 approved] |
| title_short | Recent advances in the management of Wilms' tumor [version 1; referees: 2 approved] |
| title_sort | recent advances in the management of wilms tumor version 1 referees 2 approved |
| topic | Cancer Therapeutics Cell Growth & Division Control of Gene Expression Genitourinary Cancers Medical Genetics Pediatric Oncology |
| url | https://f1000research.com/articles/6-670/v1 |
| work_keys_str_mv | AT robertoilopes recentadvancesinthemanagementofwilmstumorversion1referees2approved AT armandolorenzo recentadvancesinthemanagementofwilmstumorversion1referees2approved |