Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma
Given the numerous adverse effects of lung cancer treatment, more research on non-toxic medications is urgently needed. Curcumin (CUR) and berberine (BBR) combat drug resistance by controlling the expression of multidrug resistant pump (MDR1). Fascinatingly, combining these medications increases the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-03-01
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| Series: | Journal of Applied Biomaterials & Functional Materials |
| Online Access: | https://doi.org/10.1177/22808000241235442 |
| _version_ | 1827314801795137536 |
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| author | Ashraf Alemi Mojtaba Haghi Karamallah Mohamad Sabaghan Seyed Ahmad Hosseini Ali Veisi Somayeh Haghi Karamallah Mohammad Farokhifar |
| author_facet | Ashraf Alemi Mojtaba Haghi Karamallah Mohamad Sabaghan Seyed Ahmad Hosseini Ali Veisi Somayeh Haghi Karamallah Mohammad Farokhifar |
| author_sort | Ashraf Alemi |
| collection | DOAJ |
| description | Given the numerous adverse effects of lung cancer treatment, more research on non-toxic medications is urgently needed. Curcumin (CUR) and berberine (BBR) combat drug resistance by controlling the expression of multidrug resistant pump (MDR1). Fascinatingly, combining these medications increases the effectiveness of preventing lung cancer. Their low solubility and poor stability, however, restrict their therapeutic efficacy. Because of the improved bioavailability and increased encapsulation effectiveness of water-insoluble medicines, surfactant-based nanovesicles have recently received a great deal of attention. The current study sought to elucidate the Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma. The impact of several tween (20, 60, and 80) types with varied hydrophobic tails on BBR/CUR-TNV was evaluated. Additionally, the MDR1 activity and apoptosis rate of the BBR/CUR-TNV combination therapy were assessed. The encapsulation effectiveness of TNV was affected by the type of tween. With the TNV made from tween 60, cholesterol, and PEG (47.5: 47.5:5), more encapsulation effectiveness was attained. By combining CUR with BBR, especially when given in TNV, apoptosis increased. Additionally, when CUR and BBR were administered in combination, they significantly reduced the risk of MDR1 development. The current work suggests that the delivery of berberine and curcumin as a combination medication therapy via tween-based nanovesicles may be a potential lung cancer treatment. |
| first_indexed | 2024-04-24T22:43:28Z |
| format | Article |
| id | doaj.art-48fed83ba88c46f79590949e9063e8b7 |
| institution | Directory Open Access Journal |
| issn | 2280-8000 |
| language | English |
| last_indexed | 2024-04-24T22:43:28Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Applied Biomaterials & Functional Materials |
| spelling | doaj.art-48fed83ba88c46f79590949e9063e8b72024-03-18T17:03:57ZengSAGE PublishingJournal of Applied Biomaterials & Functional Materials2280-80002024-03-012210.1177/22808000241235442Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung CarcinomaAshraf Alemi0Mojtaba Haghi Karamallah1Mohamad Sabaghan2Seyed Ahmad Hosseini3Ali Veisi4Somayeh Haghi Karamallah5Mohammad Farokhifar6Abadan University of Medical Sciences, Abadan, IranShoushtar Faculty of Medical Sciences, Shoushtar, IranBehbahan Faculty of Medical Sciences, Behbahan, IranNutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranBehbahan Faculty of Medical Sciences, Behbahan, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranKar Higher Education Institute of Rafsanjan, Rafsanjan, IranGiven the numerous adverse effects of lung cancer treatment, more research on non-toxic medications is urgently needed. Curcumin (CUR) and berberine (BBR) combat drug resistance by controlling the expression of multidrug resistant pump (MDR1). Fascinatingly, combining these medications increases the effectiveness of preventing lung cancer. Their low solubility and poor stability, however, restrict their therapeutic efficacy. Because of the improved bioavailability and increased encapsulation effectiveness of water-insoluble medicines, surfactant-based nanovesicles have recently received a great deal of attention. The current study sought to elucidate the Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma. The impact of several tween (20, 60, and 80) types with varied hydrophobic tails on BBR/CUR-TNV was evaluated. Additionally, the MDR1 activity and apoptosis rate of the BBR/CUR-TNV combination therapy were assessed. The encapsulation effectiveness of TNV was affected by the type of tween. With the TNV made from tween 60, cholesterol, and PEG (47.5: 47.5:5), more encapsulation effectiveness was attained. By combining CUR with BBR, especially when given in TNV, apoptosis increased. Additionally, when CUR and BBR were administered in combination, they significantly reduced the risk of MDR1 development. The current work suggests that the delivery of berberine and curcumin as a combination medication therapy via tween-based nanovesicles may be a potential lung cancer treatment.https://doi.org/10.1177/22808000241235442 |
| spellingShingle | Ashraf Alemi Mojtaba Haghi Karamallah Mohamad Sabaghan Seyed Ahmad Hosseini Ali Veisi Somayeh Haghi Karamallah Mohammad Farokhifar Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma Journal of Applied Biomaterials & Functional Materials |
| title | Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma |
| title_full | Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma |
| title_fullStr | Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma |
| title_full_unstemmed | Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma |
| title_short | Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma |
| title_sort | combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1 promote apoptosis in lung carcinoma |
| url | https://doi.org/10.1177/22808000241235442 |
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