Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System
Purpose: To propose a classification of the glistening in intraocular lenses (IOL) using swept-source optical coherence tomography (SS-OCT) by means of a simple, objective and reproducible method that allows the quantification of the presence and severity of glistening. Methods: A cross-sectional st...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/6/2351 |
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| author | José Ignacio Fernández-Vigo Bárbara Burgos-Blasco Lucía De-Pablo-Gómez-de-Liaño Inés Sánchez-Guillén Virginia Albitre-Barca Susana Fernández-Aragón José Ángel Fernández-Vigo Ana Macarro-Merino |
| author_facet | José Ignacio Fernández-Vigo Bárbara Burgos-Blasco Lucía De-Pablo-Gómez-de-Liaño Inés Sánchez-Guillén Virginia Albitre-Barca Susana Fernández-Aragón José Ángel Fernández-Vigo Ana Macarro-Merino |
| author_sort | José Ignacio Fernández-Vigo |
| collection | DOAJ |
| description | Purpose: To propose a classification of the glistening in intraocular lenses (IOL) using swept-source optical coherence tomography (SS-OCT) by means of a simple, objective and reproducible method that allows the quantification of the presence and severity of glistening. Methods: A cross-sectional study on a sample of 150 eyes of 150 patients who underwent cataract surgery in at least 600 days before the exam and attended a routine examination. Each subject was examined by SS-OCT after pupil dilation, identifying the presence of glistening or hyperreflective foci (HRF) in the central area of the IOL. The degree of glistening was classified into four categories: 0: ≤5 HRF; 1: 6 to 15 HRF; 2: 16 to 30 HRF; and 3: >30 HRF. The intra and interobserver reproducibility (intraclass correlation coefficient, ICC) in the quantification and classification of the glistening were calculated. The correlation between the horizontal and vertical scan of the IOL was also assessed. Results: Glistening was present in the IOL in 42.7% of the patients. The mean number of HRF or glistening microvacuoles was 10.4 ± 26.2 (range 0 to 239). In total, 63.3% of the IOLs had a grade 0, 20% grade a 1, 6.7% grade a 2 and 10% a grade 3. The intraobserver and interobserver reproducibility were very high, both for the absolute quantification of the glistening (ICC ≥ 0.994) and for the severity scale (ICC ≥ 0.967). There was an excellent correlation in the quantification of the IOL glistening between the horizontal and vertical scans (R ≥ 0.834; <i>p</i> < 0.001). Conclusions: The use of SS-OCT makes it possible to identify, quantify and classify IOL glistening in a simple, objective and reproducible way. This technique could provide relevant information for the study of the glistening on IOLs. |
| first_indexed | 2024-03-11T06:21:58Z |
| format | Article |
| id | doaj.art-48ff0300bb334846ba5cf9bfbf824922 |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T06:21:58Z |
| publishDate | 2023-03-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-48ff0300bb334846ba5cf9bfbf8249222023-11-17T11:51:40ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126235110.3390/jcm12062351Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading SystemJosé Ignacio Fernández-Vigo0Bárbara Burgos-Blasco1Lucía De-Pablo-Gómez-de-Liaño2Inés Sánchez-Guillén3Virginia Albitre-Barca4Susana Fernández-Aragón5José Ángel Fernández-Vigo6Ana Macarro-Merino7Centro Internacional de Oftalmología Avanzada, 28010 Madrid, SpainDepartment of Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), 28040 Madrid, SpainCentro Internacional de Oftalmología Avanzada, 28010 Madrid, SpainDepartment of Ophthalmology, Hospital Perpetuo Socorro, 06010 Badajoz, SpainCentro Internacional de Oftalmología Avanzada, 28010 Madrid, SpainCentro Internacional de Oftalmología Avanzada, 28010 Madrid, SpainCentro Internacional de Oftalmología Avanzada, 28010 Madrid, SpainCentro Internacional de Oftalmología Avanzada, 28010 Madrid, SpainPurpose: To propose a classification of the glistening in intraocular lenses (IOL) using swept-source optical coherence tomography (SS-OCT) by means of a simple, objective and reproducible method that allows the quantification of the presence and severity of glistening. Methods: A cross-sectional study on a sample of 150 eyes of 150 patients who underwent cataract surgery in at least 600 days before the exam and attended a routine examination. Each subject was examined by SS-OCT after pupil dilation, identifying the presence of glistening or hyperreflective foci (HRF) in the central area of the IOL. The degree of glistening was classified into four categories: 0: ≤5 HRF; 1: 6 to 15 HRF; 2: 16 to 30 HRF; and 3: >30 HRF. The intra and interobserver reproducibility (intraclass correlation coefficient, ICC) in the quantification and classification of the glistening were calculated. The correlation between the horizontal and vertical scan of the IOL was also assessed. Results: Glistening was present in the IOL in 42.7% of the patients. The mean number of HRF or glistening microvacuoles was 10.4 ± 26.2 (range 0 to 239). In total, 63.3% of the IOLs had a grade 0, 20% grade a 1, 6.7% grade a 2 and 10% a grade 3. The intraobserver and interobserver reproducibility were very high, both for the absolute quantification of the glistening (ICC ≥ 0.994) and for the severity scale (ICC ≥ 0.967). There was an excellent correlation in the quantification of the IOL glistening between the horizontal and vertical scans (R ≥ 0.834; <i>p</i> < 0.001). Conclusions: The use of SS-OCT makes it possible to identify, quantify and classify IOL glistening in a simple, objective and reproducible way. This technique could provide relevant information for the study of the glistening on IOLs.https://www.mdpi.com/2077-0383/12/6/2351glisteningintraocular lensopacificationoptical coherence tomography |
| spellingShingle | José Ignacio Fernández-Vigo Bárbara Burgos-Blasco Lucía De-Pablo-Gómez-de-Liaño Inés Sánchez-Guillén Virginia Albitre-Barca Susana Fernández-Aragón José Ángel Fernández-Vigo Ana Macarro-Merino Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System Journal of Clinical Medicine glistening intraocular lens opacification optical coherence tomography |
| title | Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System |
| title_full | Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System |
| title_fullStr | Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System |
| title_full_unstemmed | Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System |
| title_short | Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System |
| title_sort | objective classification of glistening in implanted intraocular lenses using optical coherence tomography proposal for a new classification and grading system |
| topic | glistening intraocular lens opacification optical coherence tomography |
| url | https://www.mdpi.com/2077-0383/12/6/2351 |
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