Clinical and economic impact of COVID-19 on people with obesity in a Spanish cohort during the first pandemic peak
IntroductionCOVID-19 and obesity relationship has been extensively studied since the COVID-19 outbreak, proving obesity is a risk factor. This study aims to broaden the available information about this association and to evaluate the economic impact of obesity and the COVID-19 disease combination.Me...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1146517/full |
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| author | Torrego-Ellacuría M Torrego-Ellacuría M Rubio-Herrera MA Rubio-Herrera MA González López-Valcárcel B Fuentes-Ferrer ME Fuentes-Ferrer ME Martín V Poyato F Barber-Pérez P Santucci C Santucci C Nuñez A González-Pérez C González-Pérez C Luaces M |
| author_facet | Torrego-Ellacuría M Torrego-Ellacuría M Rubio-Herrera MA Rubio-Herrera MA González López-Valcárcel B Fuentes-Ferrer ME Fuentes-Ferrer ME Martín V Poyato F Barber-Pérez P Santucci C Santucci C Nuñez A González-Pérez C González-Pérez C Luaces M |
| author_sort | Torrego-Ellacuría M |
| collection | DOAJ |
| description | IntroductionCOVID-19 and obesity relationship has been extensively studied since the COVID-19 outbreak, proving obesity is a risk factor. This study aims to broaden the available information about this association and to evaluate the economic impact of obesity and the COVID-19 disease combination.MethodsThis retrospective study analyzed a sample of 3,402 patients admitted to a Spanish hospital with available body mass index (BMI) data.ResultsThe prevalence of obesity was 33.4%. Patients with obesity showed a higher risk of hospitalization (OR 95% ConfidenceInterval [CI]=1.46; [1.24-1.73]; p < 0.001), which increased with the obesity degree (I: OR [95% CI]=1.28 [1.06-1.55], p =0.010; II: OR [95% CI]=1.58 [1.16-2.15], p =0.004; III: OR [95% CI] =2.09 [1.31-3.34], p =0.002). Patients with type III obesity had a significantly higher risk of intensive care unit (ICU) admission (OR [95% CI]= 3.30 [1.67-6.53]; p = 0.001) and invasive mechanical ventilation (IMV) need (OR [95% CI]= 3.98 [2.00-7.94]; p<0.001). The average cost per patient was remarkably higher in patients with obesity (p = 0.007), reaching an excess cost of 28.41% in the study cohort and rising to 56.5% in patients < 70 years. The average cost per patient increased significantly with the degree of obesity (p = 0.007).DiscussionIn conclusion, our results suggest a strong association between obesity and adverse COVID-19 outcomes and higher expenditures in patients with both conditions. |
| first_indexed | 2024-03-13T07:13:48Z |
| format | Article |
| id | doaj.art-48ffc5599348418ca25373470dfbc77a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T07:13:48Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-48ffc5599348418ca25373470dfbc77a2023-06-05T14:39:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11465171146517Clinical and economic impact of COVID-19 on people with obesity in a Spanish cohort during the first pandemic peakTorrego-Ellacuría M0Torrego-Ellacuría M1Rubio-Herrera MA2Rubio-Herrera MA3González López-Valcárcel B4Fuentes-Ferrer ME5Fuentes-Ferrer ME6Martín V7Poyato F8Barber-Pérez P9Santucci C10Santucci C11Nuñez A12González-Pérez C13González-Pérez C14Luaces M15Innovation Unit, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainDepartment of Endocrinology and Nutrition, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainDepartment of Endocrinology and Nutrition, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainDepartment of Medicine, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, SpainDepartment of Quantitative Methods for Economics and Management, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, SpainDepartment of Preventive Medicine, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainResearch Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainDepartment of Market Access and Public Affairs, Novo Nordisk Pharma, Sociedad Anónima (SA.), Madrid, SpainDepartment of Clinical, Medical and Regulatory, Novo Nordisk Pharma, Sociedad Anònima (SA.), Madrid, SpainDepartment of Quantitative Methods for Economics and Management, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, SpainDepartment of Quantitative Methods for Economics and Management, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, SpainDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy0Department of Critical Care, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainInnovation Unit, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain1Department of Hospital Pharmacy, Hospital Clínico San Carlos, Instituto de Investigaciòn Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainInnovation Unit, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainIntroductionCOVID-19 and obesity relationship has been extensively studied since the COVID-19 outbreak, proving obesity is a risk factor. This study aims to broaden the available information about this association and to evaluate the economic impact of obesity and the COVID-19 disease combination.MethodsThis retrospective study analyzed a sample of 3,402 patients admitted to a Spanish hospital with available body mass index (BMI) data.ResultsThe prevalence of obesity was 33.4%. Patients with obesity showed a higher risk of hospitalization (OR 95% ConfidenceInterval [CI]=1.46; [1.24-1.73]; p < 0.001), which increased with the obesity degree (I: OR [95% CI]=1.28 [1.06-1.55], p =0.010; II: OR [95% CI]=1.58 [1.16-2.15], p =0.004; III: OR [95% CI] =2.09 [1.31-3.34], p =0.002). Patients with type III obesity had a significantly higher risk of intensive care unit (ICU) admission (OR [95% CI]= 3.30 [1.67-6.53]; p = 0.001) and invasive mechanical ventilation (IMV) need (OR [95% CI]= 3.98 [2.00-7.94]; p<0.001). The average cost per patient was remarkably higher in patients with obesity (p = 0.007), reaching an excess cost of 28.41% in the study cohort and rising to 56.5% in patients < 70 years. The average cost per patient increased significantly with the degree of obesity (p = 0.007).DiscussionIn conclusion, our results suggest a strong association between obesity and adverse COVID-19 outcomes and higher expenditures in patients with both conditions.https://www.frontiersin.org/articles/10.3389/fendo.2023.1146517/fullCOVID-19obesityinvasive mechanical ventilation (IMV)intensive care unit (ICU)economic burdenobesity comorbidities |
| spellingShingle | Torrego-Ellacuría M Torrego-Ellacuría M Rubio-Herrera MA Rubio-Herrera MA González López-Valcárcel B Fuentes-Ferrer ME Fuentes-Ferrer ME Martín V Poyato F Barber-Pérez P Santucci C Santucci C Nuñez A González-Pérez C González-Pérez C Luaces M Clinical and economic impact of COVID-19 on people with obesity in a Spanish cohort during the first pandemic peak Frontiers in Endocrinology COVID-19 obesity invasive mechanical ventilation (IMV) intensive care unit (ICU) economic burden obesity comorbidities |
| title | Clinical and economic impact of COVID-19 on people with obesity in a Spanish cohort during the first pandemic peak |
| title_full | Clinical and economic impact of COVID-19 on people with obesity in a Spanish cohort during the first pandemic peak |
| title_fullStr | Clinical and economic impact of COVID-19 on people with obesity in a Spanish cohort during the first pandemic peak |
| title_full_unstemmed | Clinical and economic impact of COVID-19 on people with obesity in a Spanish cohort during the first pandemic peak |
| title_short | Clinical and economic impact of COVID-19 on people with obesity in a Spanish cohort during the first pandemic peak |
| title_sort | clinical and economic impact of covid 19 on people with obesity in a spanish cohort during the first pandemic peak |
| topic | COVID-19 obesity invasive mechanical ventilation (IMV) intensive care unit (ICU) economic burden obesity comorbidities |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1146517/full |
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