Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.

Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the leading infectious disease causes of morbidity and mortality worldwide. Though current antibiotic regimens can cure the disease, treatment requires at least six months of drug therapy. One reason for the long duration of ther...

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Bibliographic Details
Main Authors: Mi-Sun Koo, Claudia Manca, Guibin Yang, Paul O'Brien, Nackmoon Sung, Liana Tsenova, Selvakumar Subbian, Dorothy Fallows, George Muller, Sabine Ehrt, Gilla Kaplan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3045423?pdf=render

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