Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study

Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study

Abstract Background The rise in antimicrobial resistance is a global threat responsible for about 33,000 deaths in 2015 with a particular concern for extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) and has led to a major increase in the use of carbapenems, last-resort antibiotic...

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Main Authors: Erwann Cariou, Romain Griffier, Arthur Orieux, Stein Silva, Stanislas Faguer, Thierry Seguin, Saad Nseir, Emmanuel Canet, Arnaud Desclaux, Bertrand Souweine, Kada Klouche, Olivier Guisset, Jerome Pillot, Walter Picard, Tahar Saghi, Pierre Delobel, Didier Gruson, Renaud Prevel, Alexandre Boyer
Format: Article
Language:English
Published: SpringerOpen 2023-03-01
Series:Annals of Intensive Care
Subjects:
Extended-spectrum β-lactamase-producing Enterobacterales
Non carbapenem β-lactam therapy
Antimicrobial resistance
Septic shock
Urinary tract infection
Aminoglycosides
Online Access:https://doi.org/10.1186/s13613-023-01106-z

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