Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds
Wound infection is a major problem faced during wound healing. Therefore, it is necessary to develop wound dressings with excellent antimicrobial properties. Here, a smart response system of PVA-TPE/HA-AMP/SF/ALG wound dressing was prepared by a combination of chemical cross-linking and freeze-dryin...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1338172/full |
| _version_ | 1797356943905390592 |
|---|---|
| author | Yi Chen Hongjin Qian Dandan Peng Yan Jiang Qiaolin Liu Yan Tan Longbao Feng Biao Cheng Guilan Li |
| author_facet | Yi Chen Hongjin Qian Dandan Peng Yan Jiang Qiaolin Liu Yan Tan Longbao Feng Biao Cheng Guilan Li |
| author_sort | Yi Chen |
| collection | DOAJ |
| description | Wound infection is a major problem faced during wound healing. Therefore, it is necessary to develop wound dressings with excellent antimicrobial properties. Here, a smart response system of PVA-TPE/HA-AMP/SF/ALG wound dressing was prepared by a combination of chemical cross-linking and freeze-drying methods. We grafted AMP onto HA to endow the wound dressing with bacterial resistance and slow release of AMP. At the same time, the system detects bacterial activity in real time for precise antimicrobial activity (through the use of PVA-TPE) and modulates inflammation to reduce bacterial infection (through the use of AMP). In addition, the PVA-TPE/HA-AMP/SF/ALG wound dressing has a good three-dimensional mesh structure, which promotes cell proliferation, enhances collagen deposition and angiogenesis, and thus effectively promotes rapid healing of infected wounds. Moreover, it can induce the expression of inflammatory factors such as VEGF, TNF-α, IFN-γ, IL-4 and TGF-β1 in infected wounds through the Wnt/CAMK/p-PKC signaling pathway, inhibit inflammatory responses, promote wound healing and reduce scar formation. Therefore, the PVA-TPE/HA-AMP/SF/ALG wound dressing smart response system shows great promise in infected wound healing. |
| first_indexed | 2024-03-08T14:37:08Z |
| format | Article |
| id | doaj.art-49043902458c4ace8d58e1a7542940aa |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T14:37:08Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-49043902458c4ace8d58e1a7542940aa2024-01-12T04:25:12ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-01-011110.3389/fbioe.2023.13381721338172Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected woundsYi Chen0Hongjin Qian1Dandan Peng2Yan Jiang3Qiaolin Liu4Yan Tan5Longbao Feng6Biao Cheng7Guilan Li8Department of Cadre Ward, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Cadre Ward, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Oncology, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Cadre Ward, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Oncology, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Cadre Ward, General Hospital of Southern Theater Command, Guangzhou, ChinaKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Jinan University, Guangzhou, ChinaDepartment of Burns and Plastic Surgery, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Neurosurgery, General Hospital of Southern Theater Command, Guangzhou, ChinaWound infection is a major problem faced during wound healing. Therefore, it is necessary to develop wound dressings with excellent antimicrobial properties. Here, a smart response system of PVA-TPE/HA-AMP/SF/ALG wound dressing was prepared by a combination of chemical cross-linking and freeze-drying methods. We grafted AMP onto HA to endow the wound dressing with bacterial resistance and slow release of AMP. At the same time, the system detects bacterial activity in real time for precise antimicrobial activity (through the use of PVA-TPE) and modulates inflammation to reduce bacterial infection (through the use of AMP). In addition, the PVA-TPE/HA-AMP/SF/ALG wound dressing has a good three-dimensional mesh structure, which promotes cell proliferation, enhances collagen deposition and angiogenesis, and thus effectively promotes rapid healing of infected wounds. Moreover, it can induce the expression of inflammatory factors such as VEGF, TNF-α, IFN-γ, IL-4 and TGF-β1 in infected wounds through the Wnt/CAMK/p-PKC signaling pathway, inhibit inflammatory responses, promote wound healing and reduce scar formation. Therefore, the PVA-TPE/HA-AMP/SF/ALG wound dressing smart response system shows great promise in infected wound healing.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1338172/fullantimicrobial peptidePVA-TPEwound dressingsmart responsehealing |
| spellingShingle | Yi Chen Hongjin Qian Dandan Peng Yan Jiang Qiaolin Liu Yan Tan Longbao Feng Biao Cheng Guilan Li Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds Frontiers in Bioengineering and Biotechnology antimicrobial peptide PVA-TPE wound dressing smart response healing |
| title | Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds |
| title_full | Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds |
| title_fullStr | Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds |
| title_full_unstemmed | Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds |
| title_short | Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds |
| title_sort | antimicrobial peptide modified aie visual composite wound dressing for promoting rapid healing of infected wounds |
| topic | antimicrobial peptide PVA-TPE wound dressing smart response healing |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1338172/full |
| work_keys_str_mv | AT yichen antimicrobialpeptidemodifiedaievisualcompositewounddressingforpromotingrapidhealingofinfectedwounds AT hongjinqian antimicrobialpeptidemodifiedaievisualcompositewounddressingforpromotingrapidhealingofinfectedwounds AT dandanpeng antimicrobialpeptidemodifiedaievisualcompositewounddressingforpromotingrapidhealingofinfectedwounds AT yanjiang antimicrobialpeptidemodifiedaievisualcompositewounddressingforpromotingrapidhealingofinfectedwounds AT qiaolinliu antimicrobialpeptidemodifiedaievisualcompositewounddressingforpromotingrapidhealingofinfectedwounds AT yantan antimicrobialpeptidemodifiedaievisualcompositewounddressingforpromotingrapidhealingofinfectedwounds AT longbaofeng antimicrobialpeptidemodifiedaievisualcompositewounddressingforpromotingrapidhealingofinfectedwounds AT biaocheng antimicrobialpeptidemodifiedaievisualcompositewounddressingforpromotingrapidhealingofinfectedwounds AT guilanli antimicrobialpeptidemodifiedaievisualcompositewounddressingforpromotingrapidhealingofinfectedwounds |