Anti-cancer activity of compounds from Cassia garrettiana heartwood
The ethanol extract of Cassia garrettiana heartwood showed marked inhibitory activity against several cancer cell lines including HT-29, HeLa, MCF-7 and KB cells. Therefore, its extract and compounds were investigated for their anticancer effect using the Sulforhodamine B (SRB) assay. The ethanol...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2014-04-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | http://rdo.psu.ac.th/sjstweb/journal/36-2/36-2-7.pdf |
| _version_ | 1811267492690001920 |
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| author | Supreeya Yuenyongsawad Kingkan Bunluepuech Chatchai Wattanapiromsakul Supinya Tewtrakul |
| author_facet | Supreeya Yuenyongsawad Kingkan Bunluepuech Chatchai Wattanapiromsakul Supinya Tewtrakul |
| author_sort | Supreeya Yuenyongsawad |
| collection | DOAJ |
| description | The ethanol extract of Cassia garrettiana heartwood showed marked inhibitory activity against several cancer cell
lines including HT-29, HeLa, MCF-7 and KB cells. Therefore, its extract and compounds were investigated for their anticancer
effect using the Sulforhodamine B (SRB) assay. The ethanol extract of C. garrettiana heartwood was separated to
give five compounds which are chrysophanol (1), piceatannol (2), aloe-emodin (3), emodin (4) and cassigarol E (5). Of the
tested samples, chrysophanol (1) showed the highest anti-cancer activity against KB cells (IC50 = 0.045 g/mL), aloe emodin
(3) was the most active against HT-29 (IC50 = 0.29 g/mL), emodin (4) was against HeLa cells (IC50 = 0.82 g/mL), and
cassigarol E (5) was active against MCF-7 (IC50 = 0.021 g/mL), whereas piceatannol (2) was inactive in all tested cell lines.
This is the first report of anti-cancer effect against HT-29, HeLa, MCF-7 and KB cells of C. garrettiana heartwood. |
| first_indexed | 2024-04-12T21:03:34Z |
| format | Article |
| id | doaj.art-4904bb37dc924e44b6cd7b378a98e148 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-12T21:03:34Z |
| publishDate | 2014-04-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-4904bb37dc924e44b6cd7b378a98e1482022-12-22T03:16:46ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952014-04-01362189194Anti-cancer activity of compounds from Cassia garrettiana heartwoodSupreeya Yuenyongsawad0Kingkan Bunluepuech1Chatchai Wattanapiromsakul2Supinya Tewtrakul3Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand.Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand.Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand.Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112 Thailand.The ethanol extract of Cassia garrettiana heartwood showed marked inhibitory activity against several cancer cell lines including HT-29, HeLa, MCF-7 and KB cells. Therefore, its extract and compounds were investigated for their anticancer effect using the Sulforhodamine B (SRB) assay. The ethanol extract of C. garrettiana heartwood was separated to give five compounds which are chrysophanol (1), piceatannol (2), aloe-emodin (3), emodin (4) and cassigarol E (5). Of the tested samples, chrysophanol (1) showed the highest anti-cancer activity against KB cells (IC50 = 0.045 g/mL), aloe emodin (3) was the most active against HT-29 (IC50 = 0.29 g/mL), emodin (4) was against HeLa cells (IC50 = 0.82 g/mL), and cassigarol E (5) was active against MCF-7 (IC50 = 0.021 g/mL), whereas piceatannol (2) was inactive in all tested cell lines. This is the first report of anti-cancer effect against HT-29, HeLa, MCF-7 and KB cells of C. garrettiana heartwood.http://rdo.psu.ac.th/sjstweb/journal/36-2/36-2-7.pdfanti-cancer activityCassia garrettianaCaesalpiniaceae |
| spellingShingle | Supreeya Yuenyongsawad Kingkan Bunluepuech Chatchai Wattanapiromsakul Supinya Tewtrakul Anti-cancer activity of compounds from Cassia garrettiana heartwood Songklanakarin Journal of Science and Technology (SJST) anti-cancer activity Cassia garrettiana Caesalpiniaceae |
| title | Anti-cancer activity of compounds from Cassia garrettiana heartwood |
| title_full | Anti-cancer activity of compounds from Cassia garrettiana heartwood |
| title_fullStr | Anti-cancer activity of compounds from Cassia garrettiana heartwood |
| title_full_unstemmed | Anti-cancer activity of compounds from Cassia garrettiana heartwood |
| title_short | Anti-cancer activity of compounds from Cassia garrettiana heartwood |
| title_sort | anti cancer activity of compounds from cassia garrettiana heartwood |
| topic | anti-cancer activity Cassia garrettiana Caesalpiniaceae |
| url | http://rdo.psu.ac.th/sjstweb/journal/36-2/36-2-7.pdf |
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