Apoptotic pathways in pancreatic ductal adenocarcinoma
<p>Abstract</p> <p>Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. Overall, the 5-year survival rate is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-07-01
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| Series: | Molecular Cancer |
| Online Access: | http://www.molecular-cancer.com/content/7/1/64 |
| _version_ | 1818056639033376768 |
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| author | Saur Dieter Schmid Roland M Hamacher Rainer Schneider Günter |
| author_facet | Saur Dieter Schmid Roland M Hamacher Rainer Schneider Günter |
| author_sort | Saur Dieter |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. Overall, the 5-year survival rate is less than 5% demonstrating the insufficiency of current therapies.</p> <p>Most cytotoxic therapies induce apoptosis and PDAC cells have evolved a plethora of molecular mechanisms to assure survival. We will present anti-apoptotic strategies working at the level of the death receptors, the mitochondria or involving the caspase inhibitors of the IAP family. Furthermore, the survival function of the phosphotidylinositol-3' kinase (PI3K)/AKT- and NF-kappaB-pathways are illustrated. A detailed molecular knowledge of the anti-apoptotic mechanisms of PDAC cells will help to improve therapies for this dismal disease and therapeutic strategies targeting the programmed cell death machinery are in early preclinical and clinical development.</p> |
| first_indexed | 2024-12-10T12:32:02Z |
| format | Article |
| id | doaj.art-4905524294a848fba36799736af5db71 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-10T12:32:02Z |
| publishDate | 2008-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-4905524294a848fba36799736af5db712022-12-22T01:48:46ZengBMCMolecular Cancer1476-45982008-07-01716410.1186/1476-4598-7-64Apoptotic pathways in pancreatic ductal adenocarcinomaSaur DieterSchmid Roland MHamacher RainerSchneider Günter<p>Abstract</p> <p>Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. Overall, the 5-year survival rate is less than 5% demonstrating the insufficiency of current therapies.</p> <p>Most cytotoxic therapies induce apoptosis and PDAC cells have evolved a plethora of molecular mechanisms to assure survival. We will present anti-apoptotic strategies working at the level of the death receptors, the mitochondria or involving the caspase inhibitors of the IAP family. Furthermore, the survival function of the phosphotidylinositol-3' kinase (PI3K)/AKT- and NF-kappaB-pathways are illustrated. A detailed molecular knowledge of the anti-apoptotic mechanisms of PDAC cells will help to improve therapies for this dismal disease and therapeutic strategies targeting the programmed cell death machinery are in early preclinical and clinical development.</p>http://www.molecular-cancer.com/content/7/1/64 |
| spellingShingle | Saur Dieter Schmid Roland M Hamacher Rainer Schneider Günter Apoptotic pathways in pancreatic ductal adenocarcinoma Molecular Cancer |
| title | Apoptotic pathways in pancreatic ductal adenocarcinoma |
| title_full | Apoptotic pathways in pancreatic ductal adenocarcinoma |
| title_fullStr | Apoptotic pathways in pancreatic ductal adenocarcinoma |
| title_full_unstemmed | Apoptotic pathways in pancreatic ductal adenocarcinoma |
| title_short | Apoptotic pathways in pancreatic ductal adenocarcinoma |
| title_sort | apoptotic pathways in pancreatic ductal adenocarcinoma |
| url | http://www.molecular-cancer.com/content/7/1/64 |
| work_keys_str_mv | AT saurdieter apoptoticpathwaysinpancreaticductaladenocarcinoma AT schmidrolandm apoptoticpathwaysinpancreaticductaladenocarcinoma AT hamacherrainer apoptoticpathwaysinpancreaticductaladenocarcinoma AT schneidergunter apoptoticpathwaysinpancreaticductaladenocarcinoma |