Mechanisms of endothelial dysfunction in obstructive sleep apnea
Amy Atkeson, Sanja JelicDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NYAbstract: Endothelial activation and inflammation are important mediators of accelerated atherogenesis and consequent increased cardiovascular morbi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2008-12-01
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| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/mechanisms-of-endothelial-dysfunction-in-obstructive-sleep-apnea-peer-reviewed-article-VHRM |
| _version_ | 1819179881684008960 |
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| author | Amy Atkeson Sanja Jelic |
| author_facet | Amy Atkeson Sanja Jelic |
| author_sort | Amy Atkeson |
| collection | DOAJ |
| description | Amy Atkeson, Sanja JelicDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NYAbstract: Endothelial activation and inflammation are important mediators of accelerated atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep apnea (OSA). Repetitive episodes of hypoxia/reoxygenation associated with transient cessation of breathing during sleep in OSA resemble ischemia/reperfusion injury and may be the main culprit underlying endothelial dysfunction in OSA. Additional factors such as repetitive arousals resulting in sleep fragmentation and deprivation and individual genetic suseptibility to vascular manifestations of OSA contribute to impaired endothelial function in OSA. The present review focuses on possible mechanisms that underlie endothelial activation and inflammation in OSA.Keywords: endothelial, obstructive sleep apnea, inflammation, dysfunction |
| first_indexed | 2024-12-22T22:05:30Z |
| format | Article |
| id | doaj.art-49056682b33343eeba0e70eb210dce4c |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-22T22:05:30Z |
| publishDate | 2008-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-49056682b33343eeba0e70eb210dce4c2022-12-21T18:11:00ZengDove Medical PressVascular Health and Risk Management1178-20482008-12-01Volume 4132713352400Mechanisms of endothelial dysfunction in obstructive sleep apneaAmy AtkesonSanja JelicAmy Atkeson, Sanja JelicDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NYAbstract: Endothelial activation and inflammation are important mediators of accelerated atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep apnea (OSA). Repetitive episodes of hypoxia/reoxygenation associated with transient cessation of breathing during sleep in OSA resemble ischemia/reperfusion injury and may be the main culprit underlying endothelial dysfunction in OSA. Additional factors such as repetitive arousals resulting in sleep fragmentation and deprivation and individual genetic suseptibility to vascular manifestations of OSA contribute to impaired endothelial function in OSA. The present review focuses on possible mechanisms that underlie endothelial activation and inflammation in OSA.Keywords: endothelial, obstructive sleep apnea, inflammation, dysfunctionhttps://www.dovepress.com/mechanisms-of-endothelial-dysfunction-in-obstructive-sleep-apnea-peer-reviewed-article-VHRMobstructive sleep apneaendothelial functioninflammationoxidative stresssleep fragmentationsleep deprivation |
| spellingShingle | Amy Atkeson Sanja Jelic Mechanisms of endothelial dysfunction in obstructive sleep apnea Vascular Health and Risk Management obstructive sleep apnea endothelial function inflammation oxidative stress sleep fragmentation sleep deprivation |
| title | Mechanisms of endothelial dysfunction in obstructive sleep apnea |
| title_full | Mechanisms of endothelial dysfunction in obstructive sleep apnea |
| title_fullStr | Mechanisms of endothelial dysfunction in obstructive sleep apnea |
| title_full_unstemmed | Mechanisms of endothelial dysfunction in obstructive sleep apnea |
| title_short | Mechanisms of endothelial dysfunction in obstructive sleep apnea |
| title_sort | mechanisms of endothelial dysfunction in obstructive sleep apnea |
| topic | obstructive sleep apnea endothelial function inflammation oxidative stress sleep fragmentation sleep deprivation |
| url | https://www.dovepress.com/mechanisms-of-endothelial-dysfunction-in-obstructive-sleep-apnea-peer-reviewed-article-VHRM |
| work_keys_str_mv | AT amyatkeson mechanismsofendothelialdysfunctioninobstructivesleepapnea AT sanjajelic mechanismsofendothelialdysfunctioninobstructivesleepapnea |