Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil
Epidemiological studies have demonstrated that the variability of the clinical response to infection caused by Mycobacterium leprae is associated with host genetic factors. The present study investigated the frequency of human leukocyte antigen (HLA) class II (DRB1) alleles in patients with leprosy...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2012-12-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900022&lng=en&tlng=en |
| _version_ | 1827844772313694208 |
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| author | Rita da Graça Carvalhal Frazão Corrêa Dorlene Maria Cardoso de Aquino Arlene de Jesus Mendes Caldas Humberto de Oliveira Serra Fábio França Silva Maxwellem de Jesus Costa Ferreira Elton Jonh Freitas Santos Emygdia Rosa Rêgo Barros Pires Leal Mesquita |
| author_facet | Rita da Graça Carvalhal Frazão Corrêa Dorlene Maria Cardoso de Aquino Arlene de Jesus Mendes Caldas Humberto de Oliveira Serra Fábio França Silva Maxwellem de Jesus Costa Ferreira Elton Jonh Freitas Santos Emygdia Rosa Rêgo Barros Pires Leal Mesquita |
| author_sort | Rita da Graça Carvalhal Frazão Corrêa |
| collection | DOAJ |
| description | Epidemiological studies have demonstrated that the variability of the clinical response to infection caused by Mycobacterium leprae is associated with host genetic factors. The present study investigated the frequency of human leukocyte antigen (HLA) class II (DRB1) alleles in patients with leprosy from São Luís, Maranhão, Brazil. A case-control study was performed in 85 individuals with leprosy and 85 healthy subjects. All samples were analysed via polymerase chain reaction-sequence specific oligonucleotide probes. The HLA-DRB1*16 allele showed a higher frequency in the group with leprosy [(9.41% vs. 4.12%) odds ratio (OR) = 2.41 95% confidence interval (CI) (0.96-6.08) p = 0.05], whereas the HLA-DRB1*11 allele was less frequent in the group with leprosy [(6.47% vs. 11.76%) OR = 0.51 95% CI (0.23-1.12) p = 0.09]. The frequency of HLA-DRB1* alleles between the control group and leprosy patient subgroups presenting different forms of the disease showed that the HLA-DRB1*16 (16.13% vs. 8.24%, OR = 4.10, CI = 1.27-13.27, p = 0.010) and HLA-DRB1*14 (5% vs. 3.53%, OR = 4.63, CI = 1.00-21.08, p = 0.032) alleles were significantly more frequent in patients with different clinical subtypes of leprosy. The sample size was a limitation in this study. Nevertheless, the results demonstrated the existence of a genetic susceptibility associated with the clinical forms of leprosy. The low frequency of the HLA-DRB1*11 allele should be further studied to investigate the possible protective effect of this allele. |
| first_indexed | 2024-03-12T08:47:39Z |
| format | Article |
| id | doaj.art-490739da36d247a0b1cd5876fa1eb5a8 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:47:39Z |
| publishDate | 2012-12-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-490739da36d247a0b1cd5876fa1eb5a82023-09-02T16:25:06ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602012-12-01107suppl 115015510.1590/S0074-02762012000900022S0074-02762012000900022Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, BrazilRita da Graça Carvalhal Frazão Corrêa0Dorlene Maria Cardoso de Aquino1Arlene de Jesus Mendes Caldas2Humberto de Oliveira Serra3Fábio França Silva4Maxwellem de Jesus Costa Ferreira5Elton Jonh Freitas Santos6Emygdia Rosa Rêgo Barros Pires Leal Mesquita7Universidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoEpidemiological studies have demonstrated that the variability of the clinical response to infection caused by Mycobacterium leprae is associated with host genetic factors. The present study investigated the frequency of human leukocyte antigen (HLA) class II (DRB1) alleles in patients with leprosy from São Luís, Maranhão, Brazil. A case-control study was performed in 85 individuals with leprosy and 85 healthy subjects. All samples were analysed via polymerase chain reaction-sequence specific oligonucleotide probes. The HLA-DRB1*16 allele showed a higher frequency in the group with leprosy [(9.41% vs. 4.12%) odds ratio (OR) = 2.41 95% confidence interval (CI) (0.96-6.08) p = 0.05], whereas the HLA-DRB1*11 allele was less frequent in the group with leprosy [(6.47% vs. 11.76%) OR = 0.51 95% CI (0.23-1.12) p = 0.09]. The frequency of HLA-DRB1* alleles between the control group and leprosy patient subgroups presenting different forms of the disease showed that the HLA-DRB1*16 (16.13% vs. 8.24%, OR = 4.10, CI = 1.27-13.27, p = 0.010) and HLA-DRB1*14 (5% vs. 3.53%, OR = 4.63, CI = 1.00-21.08, p = 0.032) alleles were significantly more frequent in patients with different clinical subtypes of leprosy. The sample size was a limitation in this study. Nevertheless, the results demonstrated the existence of a genetic susceptibility associated with the clinical forms of leprosy. The low frequency of the HLA-DRB1*11 allele should be further studied to investigate the possible protective effect of this allele.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900022&lng=en&tlng=enleprosyHLA-DRB1 geneassociation study |
| spellingShingle | Rita da Graça Carvalhal Frazão Corrêa Dorlene Maria Cardoso de Aquino Arlene de Jesus Mendes Caldas Humberto de Oliveira Serra Fábio França Silva Maxwellem de Jesus Costa Ferreira Elton Jonh Freitas Santos Emygdia Rosa Rêgo Barros Pires Leal Mesquita Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil Memorias do Instituto Oswaldo Cruz leprosy HLA-DRB1 gene association study |
| title | Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil |
| title_full | Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil |
| title_fullStr | Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil |
| title_full_unstemmed | Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil |
| title_short | Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil |
| title_sort | association analysis of human leukocyte antigen class ii drb1 alleles with leprosy in individuals from sao luis state of maranhao brazil |
| topic | leprosy HLA-DRB1 gene association study |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900022&lng=en&tlng=en |
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