Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese Patients
Aims: We developed an international registry to examine cardiovascular complications of COVID-19. Methods: A REDCap form was created in March 2020 at Mayo Clinic in collaboration with the International Society of Cardiomyopathy, Myocarditis and Heart Failure (ISCMF) and data were entered from April...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/10/2350 |
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| author | Akira Matsumori Matthew E. Auda Katelyn A. Bruno Katie A. Shapiro Toru Kato Toshihiro Nakamura Koji Hasegawa Ahmed Saleh Sherif Abdelrazek Hany Negm Niyata Hananta Karunawan Leslie T. Cooper DeLisa Fairweather |
| author_facet | Akira Matsumori Matthew E. Auda Katelyn A. Bruno Katie A. Shapiro Toru Kato Toshihiro Nakamura Koji Hasegawa Ahmed Saleh Sherif Abdelrazek Hany Negm Niyata Hananta Karunawan Leslie T. Cooper DeLisa Fairweather |
| author_sort | Akira Matsumori |
| collection | DOAJ |
| description | Aims: We developed an international registry to examine cardiovascular complications of COVID-19. Methods: A REDCap form was created in March 2020 at Mayo Clinic in collaboration with the International Society of Cardiomyopathy, Myocarditis and Heart Failure (ISCMF) and data were entered from April 2020 through April 2021. Results: Of the 696 patients in the COVID-19 Registry, 411 (59.2%) were male and 283 (40.8%) were female, with a sex ratio of 1.5:1 male to female. In total, 95.5% of the patients were from Japan. The average age was 52 years with 31.5% being >65 years of age. COVID-19 patients with a history of cardiovascular disease (CVD) had more pre-existing conditions including type II diabetes (<i>p</i> < 0.0001), cancer (<i>p</i> = 0.0003), obesity (<i>p</i> = 0.001), and kidney disease (<i>p</i> = 0.001). They also had a greater mortality of 10.1% compared to 1.7% in those without a history of CVD (<i>p</i> < 0.0001). The most common cardiovascular conditions in patients with a history of CVD were hypertension (33.7%), stroke (5.7%) and arrhythmias (5.1%). We found that troponin T, troponin I, brain natriuretic peptide (BNP), N-terminal pro-BNP (NT-proBNP), C-reactive protein (CRP), IL-6 and lambda immunoglobulin free light chains (Ig FLC) were elevated above reference levels in patients with COVID-19. Myocarditis is known to occur mainly in adults under the age of 50, and when we examined biomarkers in patients that were ≤50 years of age and had no history of CVD we found that a majority of patients had elevated levels of troponin T (71.4%), IL-6 (59.5%), creatine kinase/CK-MB (57.1%), D-dimer (57.8%), kappa Ig FLC (75.0%), and lambda Ig FLC (71.4%) suggesting myocardial injury and possible myocarditis. Conclusions: We report the first findings to our knowledge of cardiovascular complications from COVID-19 in the first year of the pandemic in a predominantly Japanese population. Mortality was increased by a history of CVD and pre-existing conditions including type II diabetes, cancer, obesity, and kidney disease. Our findings indicate that even in cases where no abnormalities are found in ECG or ultrasound cardiography that myocardial damage may occur, and cardiovascular and inflammatory biomarkers may be useful for the diagnosis. |
| first_indexed | 2024-03-09T20:22:14Z |
| format | Article |
| id | doaj.art-49074241a1a44d189f25b1edab15c99f |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:22:14Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-49074241a1a44d189f25b1edab15c99f2023-11-23T23:43:44ZengMDPI AGDiagnostics2075-44182022-09-011210235010.3390/diagnostics12102350Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese PatientsAkira Matsumori0Matthew E. Auda1Katelyn A. Bruno2Katie A. Shapiro3Toru Kato4Toshihiro Nakamura5Koji Hasegawa6Ahmed Saleh7Sherif Abdelrazek8Hany Negm9Niyata Hananta Karunawan10Leslie T. Cooper11DeLisa Fairweather12Clinical Research Center, Kyoto Medical Center, Kyoto 612-8555, JapanDepartment of Cardiovascular Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USADepartment of Cardiovascular Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USADepartment of Cardiovascular Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USADepartment of Clinical Research, National Hospital Organization, Tochigi Medical Center, Utsunomiya 320-8580, JapanDepartment of Cardiology, National Hospital Organization, Kyushu Medical Center, Fukuoka 810-8563, JapanDivision of Translational Research, National Hospital Organization, Kyoto Medical Center, Kyoto 602-8566, JapanKlinikum Braunschweig, Academic Hospital of Hannover Medical School, 30625 Braunschweig, GermanyDepartment of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, 79189 Bad Krozingen, GermanyCardiology and Ultrasonography Unit, Research Institute of Ophthalmology (RIO), Cairo 11261, EgyptDepartment of Cardiology and Vascular Medicine, Tugurejo General Hospital, Semarang 50185, Central Java, IndonesiaDepartment of Cardiovascular Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USADepartment of Cardiovascular Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USAAims: We developed an international registry to examine cardiovascular complications of COVID-19. Methods: A REDCap form was created in March 2020 at Mayo Clinic in collaboration with the International Society of Cardiomyopathy, Myocarditis and Heart Failure (ISCMF) and data were entered from April 2020 through April 2021. Results: Of the 696 patients in the COVID-19 Registry, 411 (59.2%) were male and 283 (40.8%) were female, with a sex ratio of 1.5:1 male to female. In total, 95.5% of the patients were from Japan. The average age was 52 years with 31.5% being >65 years of age. COVID-19 patients with a history of cardiovascular disease (CVD) had more pre-existing conditions including type II diabetes (<i>p</i> < 0.0001), cancer (<i>p</i> = 0.0003), obesity (<i>p</i> = 0.001), and kidney disease (<i>p</i> = 0.001). They also had a greater mortality of 10.1% compared to 1.7% in those without a history of CVD (<i>p</i> < 0.0001). The most common cardiovascular conditions in patients with a history of CVD were hypertension (33.7%), stroke (5.7%) and arrhythmias (5.1%). We found that troponin T, troponin I, brain natriuretic peptide (BNP), N-terminal pro-BNP (NT-proBNP), C-reactive protein (CRP), IL-6 and lambda immunoglobulin free light chains (Ig FLC) were elevated above reference levels in patients with COVID-19. Myocarditis is known to occur mainly in adults under the age of 50, and when we examined biomarkers in patients that were ≤50 years of age and had no history of CVD we found that a majority of patients had elevated levels of troponin T (71.4%), IL-6 (59.5%), creatine kinase/CK-MB (57.1%), D-dimer (57.8%), kappa Ig FLC (75.0%), and lambda Ig FLC (71.4%) suggesting myocardial injury and possible myocarditis. Conclusions: We report the first findings to our knowledge of cardiovascular complications from COVID-19 in the first year of the pandemic in a predominantly Japanese population. Mortality was increased by a history of CVD and pre-existing conditions including type II diabetes, cancer, obesity, and kidney disease. Our findings indicate that even in cases where no abnormalities are found in ECG or ultrasound cardiography that myocardial damage may occur, and cardiovascular and inflammatory biomarkers may be useful for the diagnosis.https://www.mdpi.com/2075-4418/12/10/2350myocarditisheart failurebiomarkerstroponinsex differences |
| spellingShingle | Akira Matsumori Matthew E. Auda Katelyn A. Bruno Katie A. Shapiro Toru Kato Toshihiro Nakamura Koji Hasegawa Ahmed Saleh Sherif Abdelrazek Hany Negm Niyata Hananta Karunawan Leslie T. Cooper DeLisa Fairweather Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese Patients Diagnostics myocarditis heart failure biomarkers troponin sex differences |
| title | Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese Patients |
| title_full | Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese Patients |
| title_fullStr | Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese Patients |
| title_full_unstemmed | Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese Patients |
| title_short | Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese Patients |
| title_sort | cardiovascular factors associated with covid 19 from an international registry of primarily japanese patients |
| topic | myocarditis heart failure biomarkers troponin sex differences |
| url | https://www.mdpi.com/2075-4418/12/10/2350 |
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