Cytotoxicity study of pyrazole derivatives
Pyrazolone heterocyclic compound, 3-methyl-1-phenyl-2-pyrazoline-5-one 2(a) was synthesized by condensation reaction between ethyl acetoacetate and phenyl hydrazine and was converted into their corresponding heterocyclic derivatives 2(b) to 2(f2). Their cytotoxicity effects were measured by brine sh...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bangladesh Pharmacological Society
2007-12-01
|
| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | http://www.bdjpharmacol.com/journalbdps0202/020281.pdf |
| _version_ | 1818757758815567872 |
|---|---|
| author | Nusrat Binta Ahasan and Md. Rabiul Islam |
| author_facet | Nusrat Binta Ahasan and Md. Rabiul Islam |
| author_sort | Nusrat Binta Ahasan and Md. Rabiul Islam |
| collection | DOAJ |
| description | Pyrazolone heterocyclic compound, 3-methyl-1-phenyl-2-pyrazoline-5-one 2(a) was synthesized by condensation reaction between ethyl acetoacetate and phenyl hydrazine and was converted into their corresponding heterocyclic derivatives 2(b) to 2(f2). Their cytotoxicity effects were measured by brine shrimp lethality bioassay. Among them the compounds 2(b), 2(f1), and 2(f2) were highly active according to IC50 values 19.50, 19.50 and 20 ppm respectively. The rest of compounds 2(a), 2(c), 2(d1), and 2(d2) having IC50 values 38, 33.50, 37.50, 36, 37.50 and 36 ppm in that order, were moderately active. |
| first_indexed | 2024-12-18T06:16:02Z |
| format | Article |
| id | doaj.art-490868bb14c24d43919c4f6ac940bd6b |
| institution | Directory Open Access Journal |
| issn | 1991-007X 1991-0088 |
| language | English |
| last_indexed | 2024-12-18T06:16:02Z |
| publishDate | 2007-12-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-490868bb14c24d43919c4f6ac940bd6b2022-12-21T21:18:16ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-007X1991-00882007-12-01228187Cytotoxicity study of pyrazole derivativesNusrat Binta Ahasan and Md. Rabiul IslamPyrazolone heterocyclic compound, 3-methyl-1-phenyl-2-pyrazoline-5-one 2(a) was synthesized by condensation reaction between ethyl acetoacetate and phenyl hydrazine and was converted into their corresponding heterocyclic derivatives 2(b) to 2(f2). Their cytotoxicity effects were measured by brine shrimp lethality bioassay. Among them the compounds 2(b), 2(f1), and 2(f2) were highly active according to IC50 values 19.50, 19.50 and 20 ppm respectively. The rest of compounds 2(a), 2(c), 2(d1), and 2(d2) having IC50 values 38, 33.50, 37.50, 36, 37.50 and 36 ppm in that order, were moderately active.www.bdjpharmacol.com/journalbdps0202/020281.pdfcytotoxicitydibromopyrazoleethyl acetoacetatephenyl hydrazinepyrazole |
| spellingShingle | Nusrat Binta Ahasan and Md. Rabiul Islam Cytotoxicity study of pyrazole derivatives Bangladesh Journal of Pharmacology cytotoxicity dibromopyrazole ethyl acetoacetate phenyl hydrazine pyrazole |
| title | Cytotoxicity study of pyrazole derivatives |
| title_full | Cytotoxicity study of pyrazole derivatives |
| title_fullStr | Cytotoxicity study of pyrazole derivatives |
| title_full_unstemmed | Cytotoxicity study of pyrazole derivatives |
| title_short | Cytotoxicity study of pyrazole derivatives |
| title_sort | cytotoxicity study of pyrazole derivatives |
| topic | cytotoxicity dibromopyrazole ethyl acetoacetate phenyl hydrazine pyrazole |
| url | http://www.bdjpharmacol.com/journalbdps0202/020281.pdf |
| work_keys_str_mv | AT nusratbintaahasanandmdrabiulislam cytotoxicitystudyofpyrazolederivatives |