Blue-grey hyperpigmentation in acne after vandetanib therapy and doxycycline use: A case report
Vandetanib is an oral tyrosine kinase inhibitor with cutaneous adverse effects that include the development of acne. We present a patient who underwent vandetanib therapy for stage IV medullary thyroid cancer in conjunction with the use of doxycycline for acne that developed. After vandetanib use, b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-03-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X221086316 |
| _version_ | 1828916022492528640 |
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| author | Jonah W Perlmutter Rachel C Cogan Marni C Wiseman |
| author_facet | Jonah W Perlmutter Rachel C Cogan Marni C Wiseman |
| author_sort | Jonah W Perlmutter |
| collection | DOAJ |
| description | Vandetanib is an oral tyrosine kinase inhibitor with cutaneous adverse effects that include the development of acne. We present a patient who underwent vandetanib therapy for stage IV medullary thyroid cancer in conjunction with the use of doxycycline for acne that developed. After vandetanib use, blue-grey pigmentation developed in the acne on his face, chest, back, and arms, which darkened after the use of doxycycline. We review the literature to report that this blue-grey hyperpigmentation was likely vandetanib-induced but may have been the result of both drugs being used in combination. |
| first_indexed | 2024-12-13T20:25:06Z |
| format | Article |
| id | doaj.art-49088e6aeda64b36b8eeb4711d4dc46b |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-13T20:25:06Z |
| publishDate | 2022-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-49088e6aeda64b36b8eeb4711d4dc46b2022-12-21T23:32:35ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2022-03-011010.1177/2050313X221086316Blue-grey hyperpigmentation in acne after vandetanib therapy and doxycycline use: A case reportJonah W Perlmutter0Rachel C Cogan1Marni C Wiseman2The University of Winnipeg, Winnipeg, MB, CanadaThe University of Winnipeg, Winnipeg, MB, CanadaSKiNWISE Dermatology, Winnipeg, MB, CanadaVandetanib is an oral tyrosine kinase inhibitor with cutaneous adverse effects that include the development of acne. We present a patient who underwent vandetanib therapy for stage IV medullary thyroid cancer in conjunction with the use of doxycycline for acne that developed. After vandetanib use, blue-grey pigmentation developed in the acne on his face, chest, back, and arms, which darkened after the use of doxycycline. We review the literature to report that this blue-grey hyperpigmentation was likely vandetanib-induced but may have been the result of both drugs being used in combination.https://doi.org/10.1177/2050313X221086316 |
| spellingShingle | Jonah W Perlmutter Rachel C Cogan Marni C Wiseman Blue-grey hyperpigmentation in acne after vandetanib therapy and doxycycline use: A case report SAGE Open Medical Case Reports |
| title | Blue-grey hyperpigmentation in acne after vandetanib therapy and doxycycline use: A case report |
| title_full | Blue-grey hyperpigmentation in acne after vandetanib therapy and doxycycline use: A case report |
| title_fullStr | Blue-grey hyperpigmentation in acne after vandetanib therapy and doxycycline use: A case report |
| title_full_unstemmed | Blue-grey hyperpigmentation in acne after vandetanib therapy and doxycycline use: A case report |
| title_short | Blue-grey hyperpigmentation in acne after vandetanib therapy and doxycycline use: A case report |
| title_sort | blue grey hyperpigmentation in acne after vandetanib therapy and doxycycline use a case report |
| url | https://doi.org/10.1177/2050313X221086316 |
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