Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity
The relationship of copper dyshomeostasis with neurodegenerative diseases has become evident in the last years. Because of the major role that this metal ion plays in biological processes, most of which being located in the brain, it is not surprising that changes in its distribution are closely rel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2015-09-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/1.4921314 |
| _version_ | 1819160294055739392 |
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| author | Patrick Gamez Ana B. Caballero |
| author_facet | Patrick Gamez Ana B. Caballero |
| author_sort | Patrick Gamez |
| collection | DOAJ |
| description | The relationship of copper dyshomeostasis with neurodegenerative diseases has become evident in the last years. Because of the major role that this metal ion plays in biological processes, most of which being located in the brain, it is not surprising that changes in its distribution are closely related with the advent of neurodegenerative disorders such as Alzheimer’s disease (AD). An increasing number of works have dealt with this subject in the last years, and opened an intense debate in some points while raising new questions that still remain unanswered. This revision work puts together and discusses the latest findings and insights on how copper ions are involved in AD progression, including its interaction with Aβ and its consequently induced aggregation. |
| first_indexed | 2024-12-22T16:54:09Z |
| format | Article |
| id | doaj.art-4909d51f09ec4c168051b0ab835e4035 |
| institution | Directory Open Access Journal |
| issn | 2158-3226 |
| language | English |
| last_indexed | 2024-12-22T16:54:09Z |
| publishDate | 2015-09-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | AIP Advances |
| spelling | doaj.art-4909d51f09ec4c168051b0ab835e40352022-12-21T18:19:30ZengAIP Publishing LLCAIP Advances2158-32262015-09-0159092503092503-1210.1063/1.4921314005595ADVCopper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicityPatrick Gamez0Ana B. Caballero1Departament de Química Inorgànica, QBI, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, SpainDepartament de Química Inorgànica, QBI, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, SpainThe relationship of copper dyshomeostasis with neurodegenerative diseases has become evident in the last years. Because of the major role that this metal ion plays in biological processes, most of which being located in the brain, it is not surprising that changes in its distribution are closely related with the advent of neurodegenerative disorders such as Alzheimer’s disease (AD). An increasing number of works have dealt with this subject in the last years, and opened an intense debate in some points while raising new questions that still remain unanswered. This revision work puts together and discusses the latest findings and insights on how copper ions are involved in AD progression, including its interaction with Aβ and its consequently induced aggregation.http://dx.doi.org/10.1063/1.4921314 |
| spellingShingle | Patrick Gamez Ana B. Caballero Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity AIP Advances |
| title | Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity |
| title_full | Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity |
| title_fullStr | Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity |
| title_full_unstemmed | Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity |
| title_short | Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity |
| title_sort | copper in alzheimer s disease implications in amyloid aggregation and neurotoxicity |
| url | http://dx.doi.org/10.1063/1.4921314 |
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