| Summary: | Sweet wormwood (<i>Artemisia annua</i> L.) valorization is gaining importance due to the presence of the health-promoting bioactive compound, artemisinin. Considering the wide possible application of artemisinin drug formulations, new, greener technologies in their production are welcome. In this study, artemisinin was extracted from <i>A. annua</i> leaves using green extraction technologies (ultrasound-assisted extraction, supercritical CO<sub>2</sub> extraction, deep eutectic solvent extraction and subcritical water extraction) in combination with green solvents. Artemisinin was present up to 3.21 µg/mg<sub>dw</sub>. Among the different green extraction techniques, HPLC data revealed supercritical CO<sub>2</sub> (SCO<sub>2</sub>) extracts to exhibit the highest yield of artemisinin due to the solvent non-polar properties. Additionally, the volatile compounds profile of SCO<sub>2</sub> extract was determined, with camphor (12.23%), arteannuin b (15.29%) and artemisia ketone (10.97%) as the most abundant compounds. Obtained results encourage the use of green extraction techniques for the separation of artemisinin and are expected to find potential in pharmaceutical, cosmetic and food applications.
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