Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reaction
Summary: Abnormal accumulation of hydrogen peroxide (H2O2) in the tumor microenvironment is associated with altered metabolism, abnormal proliferation of tumor cells, and changes in the tumor microenvironment. Based on this phenomenon, we have developed manganese-doped zeolitic imidazolate framework...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224006953 |
| _version_ | 1797249072573186048 |
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| author | Junjie Zheng Lin Huang Jinying Wang Shiqiang Zhuo Gaofeng Huang |
| author_facet | Junjie Zheng Lin Huang Jinying Wang Shiqiang Zhuo Gaofeng Huang |
| author_sort | Junjie Zheng |
| collection | DOAJ |
| description | Summary: Abnormal accumulation of hydrogen peroxide (H2O2) in the tumor microenvironment is associated with altered metabolism, abnormal proliferation of tumor cells, and changes in the tumor microenvironment. Based on this phenomenon, we have developed manganese-doped zeolitic imidazolate frameworks (Mn-ZIF) nanozymes, which exhibit superior peroxidase (POD)-like activity and enhanced cytotoxicity. Inside the tumor, the H2O2 is catalyzed by Mn-ZIF nanozymes through the Fenton reaction to generate more potent hydroxyl radicals (·OH), further increasing the local reactive oxygen species (ROS) levels in tumor cells and inducing tumor cell death. Meanwhile, the removal of H2O2 in the tumor microenvironment reduces tumor proliferation. We have confirmed the anti-tumor effect of these particles in an in situ osteosarcoma (OS) model, providing a direction for the future design of hybrid nanozyme drug delivery systems. |
| first_indexed | 2024-04-24T20:24:40Z |
| format | Article |
| id | doaj.art-490b9727ee12419aab454baeabee514c |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-24T20:24:40Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-490b9727ee12419aab454baeabee514c2024-03-22T05:40:27ZengElsevieriScience2589-00422024-04-01274109474Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reactionJunjie Zheng0Lin Huang1Jinying Wang2Shiqiang Zhuo3Gaofeng Huang4Department of Orthopedics, Shanghai Sixth People’s Hospital Fujian, No.16, Luoshan Section, Jinguang Road, Jinjiang 362216, ChinaDepartment of Orthopedics, Shanghai Sixth People’s Hospital Fujian, No.16, Luoshan Section, Jinguang Road, Jinjiang 362216, ChinaDepartment of Orthopedics, Shanghai Sixth People’s Hospital Fujian, No.16, Luoshan Section, Jinguang Road, Jinjiang 362216, ChinaDepartment of Orthopedics, Shanghai Sixth People’s Hospital Fujian, No.16, Luoshan Section, Jinguang Road, Jinjiang 362216, ChinaDepartment of Orthopedics, Shanghai Sixth People’s Hospital Fujian, No.16, Luoshan Section, Jinguang Road, Jinjiang 362216, China; Corresponding authorSummary: Abnormal accumulation of hydrogen peroxide (H2O2) in the tumor microenvironment is associated with altered metabolism, abnormal proliferation of tumor cells, and changes in the tumor microenvironment. Based on this phenomenon, we have developed manganese-doped zeolitic imidazolate frameworks (Mn-ZIF) nanozymes, which exhibit superior peroxidase (POD)-like activity and enhanced cytotoxicity. Inside the tumor, the H2O2 is catalyzed by Mn-ZIF nanozymes through the Fenton reaction to generate more potent hydroxyl radicals (·OH), further increasing the local reactive oxygen species (ROS) levels in tumor cells and inducing tumor cell death. Meanwhile, the removal of H2O2 in the tumor microenvironment reduces tumor proliferation. We have confirmed the anti-tumor effect of these particles in an in situ osteosarcoma (OS) model, providing a direction for the future design of hybrid nanozyme drug delivery systems.http://www.sciencedirect.com/science/article/pii/S2589004224006953Materials chemistryBiomedical materials |
| spellingShingle | Junjie Zheng Lin Huang Jinying Wang Shiqiang Zhuo Gaofeng Huang Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reaction iScience Materials chemistry Biomedical materials |
| title | Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reaction |
| title_full | Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reaction |
| title_fullStr | Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reaction |
| title_full_unstemmed | Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reaction |
| title_short | Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reaction |
| title_sort | hybridized nanozymes for anti osteosarcoma therapy via the fenton reaction |
| topic | Materials chemistry Biomedical materials |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224006953 |
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