Maternal adverse childhood experiences and infant subcortical brain volume
Background: A large body of research supports the deleterious effects of adverse childhood experiences (ACEs) on disease susceptibility and health for both the exposed individual and the next generation. It is likely that there is an intergenerational transmission of risk from mother to child; howev...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289522000625 |
| _version_ | 1811187883529207808 |
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| author | Catherine H. Demers Benjamin L. Hankin Ella-Marie P. Hennessey Mercedes Hoeflich Haase Maria M. Bagonis Sun Hyung Kim John H. Gilmore M. Camille Hoffman Martin A. Styner Elysia Poggi Davis |
| author_facet | Catherine H. Demers Benjamin L. Hankin Ella-Marie P. Hennessey Mercedes Hoeflich Haase Maria M. Bagonis Sun Hyung Kim John H. Gilmore M. Camille Hoffman Martin A. Styner Elysia Poggi Davis |
| author_sort | Catherine H. Demers |
| collection | DOAJ |
| description | Background: A large body of research supports the deleterious effects of adverse childhood experiences (ACEs) on disease susceptibility and health for both the exposed individual and the next generation. It is likely that there is an intergenerational transmission of risk from mother to child; however, the mechanisms through which such risk is conferred remain unknown. The current study evaluated the association between maternal ACEs, neonatal brain development of the amygdala and hippocampus, and later infant negative emotionality at six months of age. Methods: The sample included 85 mother-infant dyads (44 female infants) from a longitudinal study. Maternal ACEs were assessed with the Adverse Childhood Experiences Questionnaire (ACE-Q) and neonatal hippocampal and amygdala volume was assessed using structural magnetic resonance imaging (MRI). Infant negative emotionality was assessed at 6 months using the Infant Behavior Questionnaire (IBQ). Results: Multivariate analyses demonstrated that maternal ACEs were associated with bilateral amygdala volume (F(2,78) = 3.697,p = .029). Specifically, higher maternal ACEs were associated with smaller left (β = -0.220, t(79) = -2.661, p = .009, R2= 0.494, and right (β = −0.167, t(79) = -2.043, p = .044, R2= 0.501) amygdala volume. No significant association between maternal ACEs and bilateral hippocampal volume (F(2,78) = 0.215,p = .0807) was found. Follow-up regression analyses demonstrated that both high maternal ACEs and smaller left amygdala volume were associated with higher infant negative emotionality at six months of age (β = .232, p = .040, R2= 0.094, and β = −0.337, p = .022, R2= 0.16, respectively) although statistically significant mediation of this effect was not observed (Indirect effect = 0.0187, 95% CI [-0.0016-0.0557]). Conclusions: Maternal ACEs are associated with both newborn amygdala volume and subsequent infant negative emotionality. These findings linking maternal adverse childhood experiences and infant brain development and temperament provide evidence to support the intergenerational transmission of adversity from mother to child. |
| first_indexed | 2024-04-11T14:11:07Z |
| format | Article |
| id | doaj.art-490ca09cdfd644ceb3788503edc7871d |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-04-11T14:11:07Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-490ca09cdfd644ceb3788503edc7871d2022-12-22T04:19:42ZengElsevierNeurobiology of Stress2352-28952022-11-0121100487Maternal adverse childhood experiences and infant subcortical brain volumeCatherine H. Demers0Benjamin L. Hankin1Ella-Marie P. Hennessey2Mercedes Hoeflich Haase3Maria M. Bagonis4Sun Hyung Kim5John H. Gilmore6M. Camille Hoffman7Martin A. Styner8Elysia Poggi Davis9Department of Psychology, University of Denver, Denver, CO, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Corresponding author. University of Denver, Department of Psychology, 2155 South Race Street, Denver, CO, 80208-3500, USA.Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, USADepartment of Psychology, University of Denver, Denver, CO, USADepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; PrimeNeuro, Durham, NC, USADepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Obstetrics and Gynecology, Division of Maternal and Fetal Medicine, University of Colorado Denver School of Medicine, Aurora, CO, USADepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Psychology, University of Denver, Denver, CO, USA; Department of Pediatrics, University of California Irvine, Irvine, CA, USABackground: A large body of research supports the deleterious effects of adverse childhood experiences (ACEs) on disease susceptibility and health for both the exposed individual and the next generation. It is likely that there is an intergenerational transmission of risk from mother to child; however, the mechanisms through which such risk is conferred remain unknown. The current study evaluated the association between maternal ACEs, neonatal brain development of the amygdala and hippocampus, and later infant negative emotionality at six months of age. Methods: The sample included 85 mother-infant dyads (44 female infants) from a longitudinal study. Maternal ACEs were assessed with the Adverse Childhood Experiences Questionnaire (ACE-Q) and neonatal hippocampal and amygdala volume was assessed using structural magnetic resonance imaging (MRI). Infant negative emotionality was assessed at 6 months using the Infant Behavior Questionnaire (IBQ). Results: Multivariate analyses demonstrated that maternal ACEs were associated with bilateral amygdala volume (F(2,78) = 3.697,p = .029). Specifically, higher maternal ACEs were associated with smaller left (β = -0.220, t(79) = -2.661, p = .009, R2= 0.494, and right (β = −0.167, t(79) = -2.043, p = .044, R2= 0.501) amygdala volume. No significant association between maternal ACEs and bilateral hippocampal volume (F(2,78) = 0.215,p = .0807) was found. Follow-up regression analyses demonstrated that both high maternal ACEs and smaller left amygdala volume were associated with higher infant negative emotionality at six months of age (β = .232, p = .040, R2= 0.094, and β = −0.337, p = .022, R2= 0.16, respectively) although statistically significant mediation of this effect was not observed (Indirect effect = 0.0187, 95% CI [-0.0016-0.0557]). Conclusions: Maternal ACEs are associated with both newborn amygdala volume and subsequent infant negative emotionality. These findings linking maternal adverse childhood experiences and infant brain development and temperament provide evidence to support the intergenerational transmission of adversity from mother to child.http://www.sciencedirect.com/science/article/pii/S2352289522000625Maternal adverse childhood experiencesAmygdalaHippocampusGray matter volumeNegative emotionalityIntergenerational transmission |
| spellingShingle | Catherine H. Demers Benjamin L. Hankin Ella-Marie P. Hennessey Mercedes Hoeflich Haase Maria M. Bagonis Sun Hyung Kim John H. Gilmore M. Camille Hoffman Martin A. Styner Elysia Poggi Davis Maternal adverse childhood experiences and infant subcortical brain volume Neurobiology of Stress Maternal adverse childhood experiences Amygdala Hippocampus Gray matter volume Negative emotionality Intergenerational transmission |
| title | Maternal adverse childhood experiences and infant subcortical brain volume |
| title_full | Maternal adverse childhood experiences and infant subcortical brain volume |
| title_fullStr | Maternal adverse childhood experiences and infant subcortical brain volume |
| title_full_unstemmed | Maternal adverse childhood experiences and infant subcortical brain volume |
| title_short | Maternal adverse childhood experiences and infant subcortical brain volume |
| title_sort | maternal adverse childhood experiences and infant subcortical brain volume |
| topic | Maternal adverse childhood experiences Amygdala Hippocampus Gray matter volume Negative emotionality Intergenerational transmission |
| url | http://www.sciencedirect.com/science/article/pii/S2352289522000625 |
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