The Impact of Chlorhexidine Mucoadhesive Gel in the Prevention of Ventilator-Associated Pneumonia: A Randomized Clinical Trial
Objective: Ventilator-associated pneumonia is the common cause of morbidity and mortality in the intensivecare unit. Due to the antimicrobial effect of chlorhexidine, and the long-lasting result of mucoadhesive drugs,this study aimed to determine the effect of chlorhexidine mucoadhesive gel on the p...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2023-01-01
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| Series: | Bulletin of Emergency and Trauma |
| Subjects: | |
| Online Access: | https://beat.sums.ac.ir/article_49056_a8f7ac3b0c6d3b2c282d53a74f0a06c4.pdf |
| _version_ | 1811169219284303872 |
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| author | Faramarz Dobakhti Ali Zargar Taraneh Naghibi |
| author_facet | Faramarz Dobakhti Ali Zargar Taraneh Naghibi |
| author_sort | Faramarz Dobakhti |
| collection | DOAJ |
| description | Objective: Ventilator-associated pneumonia is the common cause of morbidity and mortality in the intensivecare unit. Due to the antimicrobial effect of chlorhexidine, and the long-lasting result of mucoadhesive drugs,this study aimed to determine the effect of chlorhexidine mucoadhesive gel on the prevention of ventilatorassociatedpneumonia in critical patients.Method: In this clinical trial, 64 ventilated patients were selected and randomly allocated into two groups. Thefirst group received 0.2% chlorhexidine mucoadhesive gel and the second group received 0.2% chlorhexidinesolution as a mouthwash. Every three days, the incidence of ventilator-associated pneumonia was evaluatedby the clinical score of pulmonary infection. The data were analyzed by SPSS statistical software version 20.Results: There was no statistically significant difference in demographic characteristics between the twogroups. In the control group, 25% of the patients had ventilator-associated pneumonia, while it was only 15.6%in the intervention group; however, the incidence of ventilator-associated pneumonia revealed no significantdifference between the two groups (HR ratio, 0.86; 95% confidence interval, 0.49 to 1.83 p=0.356).In addition,there was no statistically significant difference between the number of days connected to the ventilator(p=0.854), the number of days hospitalized in the intensive care unit (p=0.423), and the death rate (p=0.634)between the two groups.Conclusion: Although no significant statistical difference was detected between chlorhexidine mucoadhesivegel and chlorhexidine solution in the prevention of ventilator-associated pneumonia, the incidence of pneumoniain the mucoadhesive gel group was clinically less than in the control group. It is better to repeat the study witha larger statistical population. |
| first_indexed | 2024-04-10T16:38:47Z |
| format | Article |
| id | doaj.art-490df957e3494e9fbe974a7c251a508f |
| institution | Directory Open Access Journal |
| issn | 2322-2522 2322-3960 |
| language | English |
| last_indexed | 2024-04-10T16:38:47Z |
| publishDate | 2023-01-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Bulletin of Emergency and Trauma |
| spelling | doaj.art-490df957e3494e9fbe974a7c251a508f2023-02-08T09:17:10ZengShiraz University of Medical SciencesBulletin of Emergency and Trauma2322-25222322-39602023-01-01111263110.30476/beat.2023.97509.140649056The Impact of Chlorhexidine Mucoadhesive Gel in the Prevention of Ventilator-Associated Pneumonia: A Randomized Clinical TrialFaramarz Dobakhti0Ali Zargar1Taraneh Naghibi2Department of Pharmaceutics, school of pharmacy, Zanjan university of medical ‎sciences, Zanjan, IranResearch committee, school of medicine, Zanjan university of medical sciences, ‎Zanjan, IranDepartment of anesthesiology and critical care medicine‎, school of medicine, ‎Zanjan university of medical sciences, Zanjan, IranObjective: Ventilator-associated pneumonia is the common cause of morbidity and mortality in the intensivecare unit. Due to the antimicrobial effect of chlorhexidine, and the long-lasting result of mucoadhesive drugs,this study aimed to determine the effect of chlorhexidine mucoadhesive gel on the prevention of ventilatorassociatedpneumonia in critical patients.Method: In this clinical trial, 64 ventilated patients were selected and randomly allocated into two groups. Thefirst group received 0.2% chlorhexidine mucoadhesive gel and the second group received 0.2% chlorhexidinesolution as a mouthwash. Every three days, the incidence of ventilator-associated pneumonia was evaluatedby the clinical score of pulmonary infection. The data were analyzed by SPSS statistical software version 20.Results: There was no statistically significant difference in demographic characteristics between the twogroups. In the control group, 25% of the patients had ventilator-associated pneumonia, while it was only 15.6%in the intervention group; however, the incidence of ventilator-associated pneumonia revealed no significantdifference between the two groups (HR ratio, 0.86; 95% confidence interval, 0.49 to 1.83 p=0.356).In addition,there was no statistically significant difference between the number of days connected to the ventilator(p=0.854), the number of days hospitalized in the intensive care unit (p=0.423), and the death rate (p=0.634)between the two groups.Conclusion: Although no significant statistical difference was detected between chlorhexidine mucoadhesivegel and chlorhexidine solution in the prevention of ventilator-associated pneumonia, the incidence of pneumoniain the mucoadhesive gel group was clinically less than in the control group. It is better to repeat the study witha larger statistical population.https://beat.sums.ac.ir/article_49056_a8f7ac3b0c6d3b2c282d53a74f0a06c4.pdfpneumoniaventilator-associatedchlorhexidinemucoadhesiveprevention |
| spellingShingle | Faramarz Dobakhti Ali Zargar Taraneh Naghibi The Impact of Chlorhexidine Mucoadhesive Gel in the Prevention of Ventilator-Associated Pneumonia: A Randomized Clinical Trial Bulletin of Emergency and Trauma pneumonia ventilator-associated chlorhexidine mucoadhesive prevention |
| title | The Impact of Chlorhexidine Mucoadhesive Gel in the Prevention of Ventilator-Associated Pneumonia: A Randomized Clinical Trial |
| title_full | The Impact of Chlorhexidine Mucoadhesive Gel in the Prevention of Ventilator-Associated Pneumonia: A Randomized Clinical Trial |
| title_fullStr | The Impact of Chlorhexidine Mucoadhesive Gel in the Prevention of Ventilator-Associated Pneumonia: A Randomized Clinical Trial |
| title_full_unstemmed | The Impact of Chlorhexidine Mucoadhesive Gel in the Prevention of Ventilator-Associated Pneumonia: A Randomized Clinical Trial |
| title_short | The Impact of Chlorhexidine Mucoadhesive Gel in the Prevention of Ventilator-Associated Pneumonia: A Randomized Clinical Trial |
| title_sort | impact of chlorhexidine mucoadhesive gel in the prevention of ventilator associated pneumonia a randomized clinical trial |
| topic | pneumonia ventilator-associated chlorhexidine mucoadhesive prevention |
| url | https://beat.sums.ac.ir/article_49056_a8f7ac3b0c6d3b2c282d53a74f0a06c4.pdf |
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