Addressing Spaceflight Biology through the Lens of a Histologist–Embryologist
Embryogenesis and fetal development are highly delicate and error-prone processes in their core physiology, let alone if stress-associated factors and conditions are involved. Space radiation and altered gravity are factors that could radically affect fertility and pregnancy and compromise a physiol...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/2/588 |
| _version_ | 1827756724126220288 |
|---|---|
| author | Paschalis Theotokis Maria Eleni Manthou Theodora-Eleftheria Deftereou Dimosthenis Miliaras Soultana Meditskou |
| author_facet | Paschalis Theotokis Maria Eleni Manthou Theodora-Eleftheria Deftereou Dimosthenis Miliaras Soultana Meditskou |
| author_sort | Paschalis Theotokis |
| collection | DOAJ |
| description | Embryogenesis and fetal development are highly delicate and error-prone processes in their core physiology, let alone if stress-associated factors and conditions are involved. Space radiation and altered gravity are factors that could radically affect fertility and pregnancy and compromise a physiological organogenesis. Unfortunately, there is a dearth of information examining the effects of cosmic exposures on reproductive and proliferating outcomes with regard to mammalian embryonic development. However, explicit attention has been given to investigations exploring discrete structures and neural networks such as the vestibular system, an entity that is viewed as the sixth sense and organically controls gravity beginning with the prenatal period. The role of the gut microbiome, a newly acknowledged field of research in the space community, is also being challenged to be added in forthcoming experimental protocols. This review discusses the data that have surfaced from simulations or actual space expeditions and addresses developmental adaptations at the histological level induced by an extraterrestrial milieu. |
| first_indexed | 2024-03-11T08:32:22Z |
| format | Article |
| id | doaj.art-4911b71f1e144b36968beea888ca43e5 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:32:22Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-4911b71f1e144b36968beea888ca43e52023-11-16T21:43:21ZengMDPI AGLife2075-17292023-02-0113258810.3390/life13020588Addressing Spaceflight Biology through the Lens of a Histologist–EmbryologistPaschalis Theotokis0Maria Eleni Manthou1Theodora-Eleftheria Deftereou2Dimosthenis Miliaras3Soultana Meditskou4Laboratory of Histology and Embryology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Histology and Embryology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Histology and Embryology, Democritus University of Thrace, 69100 Alexandroupolis, GreeceLaboratory of Histology and Embryology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Histology and Embryology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceEmbryogenesis and fetal development are highly delicate and error-prone processes in their core physiology, let alone if stress-associated factors and conditions are involved. Space radiation and altered gravity are factors that could radically affect fertility and pregnancy and compromise a physiological organogenesis. Unfortunately, there is a dearth of information examining the effects of cosmic exposures on reproductive and proliferating outcomes with regard to mammalian embryonic development. However, explicit attention has been given to investigations exploring discrete structures and neural networks such as the vestibular system, an entity that is viewed as the sixth sense and organically controls gravity beginning with the prenatal period. The role of the gut microbiome, a newly acknowledged field of research in the space community, is also being challenged to be added in forthcoming experimental protocols. This review discusses the data that have surfaced from simulations or actual space expeditions and addresses developmental adaptations at the histological level induced by an extraterrestrial milieu.https://www.mdpi.com/2075-1729/13/2/588microgravityradiationorganogenesisvestibular systembrain plasticitygut microbiome |
| spellingShingle | Paschalis Theotokis Maria Eleni Manthou Theodora-Eleftheria Deftereou Dimosthenis Miliaras Soultana Meditskou Addressing Spaceflight Biology through the Lens of a Histologist–Embryologist Life microgravity radiation organogenesis vestibular system brain plasticity gut microbiome |
| title | Addressing Spaceflight Biology through the Lens of a Histologist–Embryologist |
| title_full | Addressing Spaceflight Biology through the Lens of a Histologist–Embryologist |
| title_fullStr | Addressing Spaceflight Biology through the Lens of a Histologist–Embryologist |
| title_full_unstemmed | Addressing Spaceflight Biology through the Lens of a Histologist–Embryologist |
| title_short | Addressing Spaceflight Biology through the Lens of a Histologist–Embryologist |
| title_sort | addressing spaceflight biology through the lens of a histologist embryologist |
| topic | microgravity radiation organogenesis vestibular system brain plasticity gut microbiome |
| url | https://www.mdpi.com/2075-1729/13/2/588 |
| work_keys_str_mv | AT paschalistheotokis addressingspaceflightbiologythroughthelensofahistologistembryologist AT mariaelenimanthou addressingspaceflightbiologythroughthelensofahistologistembryologist AT theodoraeleftheriadeftereou addressingspaceflightbiologythroughthelensofahistologistembryologist AT dimosthenismiliaras addressingspaceflightbiologythroughthelensofahistologistembryologist AT soultanameditskou addressingspaceflightbiologythroughthelensofahistologistembryologist |