A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab
A 76-year-old man was admitted to our hospital with cough and dyspnea. He was diagnosed with advanced lung cancer. Nivolumab was given as second-line treatment, cytotoxic chemotherapy was given as third-line treatment, and nivolumab re-challenge was given as fourth-line treatment. Thereafter, 41 che...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007119303405 |
| _version_ | 1817985379095019520 |
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| author | Keima Ito Tetsuya Oguri Norihisa Takeda Kensuke Fukumitsu Satoshi Fukuda Yoshihiro Kanemitsu Tomoko Tajiri Hirotsugu Ohkubo Masaya Takemura Ken Maeno Yutaka Ito Akio Niimi |
| author_facet | Keima Ito Tetsuya Oguri Norihisa Takeda Kensuke Fukumitsu Satoshi Fukuda Yoshihiro Kanemitsu Tomoko Tajiri Hirotsugu Ohkubo Masaya Takemura Ken Maeno Yutaka Ito Akio Niimi |
| author_sort | Keima Ito |
| collection | DOAJ |
| description | A 76-year-old man was admitted to our hospital with cough and dyspnea. He was diagnosed with advanced lung cancer. Nivolumab was given as second-line treatment, cytotoxic chemotherapy was given as third-line treatment, and nivolumab re-challenge was given as fourth-line treatment. Thereafter, 41 chemotherapy courses were administered over 2 years. Currently, he is being followed with no recurrence at least 10 months after treatment. Thus, the case of a patient with advanced lung cancer who was previously unsuccessfully treated with nivolumab and then demonstrated a long-term clinical response to a re-challenge with nivolumab after cytotoxic chemotherapy and radiation therapy is presented. Keywords: Lung cancer, Nivolumab, Immune checkpoint inhibitors, PD-L1 |
| first_indexed | 2024-04-13T23:56:25Z |
| format | Article |
| id | doaj.art-49156b3a17f64e7d80a417c3d4be828f |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-04-13T23:56:25Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-49156b3a17f64e7d80a417c3d4be828f2022-12-22T02:23:51ZengElsevierRespiratory Medicine Case Reports2213-00712020-01-0129A case of non-small cell lung cancer with long-term response after re-challenge with nivolumabKeima Ito0Tetsuya Oguri1Norihisa Takeda2Kensuke Fukumitsu3Satoshi Fukuda4Yoshihiro Kanemitsu5Tomoko Tajiri6Hirotsugu Ohkubo7Masaya Takemura8Ken Maeno9Yutaka Ito10Akio Niimi11Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Department of Education and Research Center for Community Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Corresponding author. 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Department of Education and Research Center for Community Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanA 76-year-old man was admitted to our hospital with cough and dyspnea. He was diagnosed with advanced lung cancer. Nivolumab was given as second-line treatment, cytotoxic chemotherapy was given as third-line treatment, and nivolumab re-challenge was given as fourth-line treatment. Thereafter, 41 chemotherapy courses were administered over 2 years. Currently, he is being followed with no recurrence at least 10 months after treatment. Thus, the case of a patient with advanced lung cancer who was previously unsuccessfully treated with nivolumab and then demonstrated a long-term clinical response to a re-challenge with nivolumab after cytotoxic chemotherapy and radiation therapy is presented. Keywords: Lung cancer, Nivolumab, Immune checkpoint inhibitors, PD-L1http://www.sciencedirect.com/science/article/pii/S2213007119303405 |
| spellingShingle | Keima Ito Tetsuya Oguri Norihisa Takeda Kensuke Fukumitsu Satoshi Fukuda Yoshihiro Kanemitsu Tomoko Tajiri Hirotsugu Ohkubo Masaya Takemura Ken Maeno Yutaka Ito Akio Niimi A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab Respiratory Medicine Case Reports |
| title | A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab |
| title_full | A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab |
| title_fullStr | A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab |
| title_full_unstemmed | A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab |
| title_short | A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab |
| title_sort | case of non small cell lung cancer with long term response after re challenge with nivolumab |
| url | http://www.sciencedirect.com/science/article/pii/S2213007119303405 |
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