PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes

PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes

Objective: Brown adipocytes play a key role in maintaining body temperature as well as glucose and lipid homeostasis. However, brown adipocytes need to adapt their thermogenic activity and substrate utilization to changes in nutrient availability. Amongst the multiple factors influencing brown adipo...

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Bibliographic Details
Main Authors: Jiefu Wang, Yasuhiro Onogi, Martin Krueger, Josef Oeckl, Ruth Karlina, Inderjeet Singh, Stefanie M. Hauck, Regina Feederle, Yongguo Li, Siegfried Ussar
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Molecular Metabolism
Subjects:
Brown adipocytes
Lysosomal acidification
Proton-coupled amino acid transporter
Transporter translocation across membranes
V-ATPase assembly
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000771

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http://www.sciencedirect.com/science/article/pii/S2212877822000771

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