Complementary Therapies and Their Association with Problems in Therapeutic Adherence to Conventional Synthetic DMARDs in Rheumatoid Arthritis: A Cross-Sectional Study
The use of complementary therapies is highly prevalent among patients with rheumatoid arthritis (RA). Nevertheless, the use of complementary medicine could involve problems in the following of scientifically accepted treatments. To date, there is limited information regarding the association of nonc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/12/1/49 |
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| author | Aline Priscilla Santiago-Garcia Jorge Ivan Gamez-Nava Felipe Alexis Avalos-Salgado Sergio Cerpa-Cruz Edna Lizeth Amaya-Cabrera Sergio Gutierrez-Ureña Cesar Arturo Nava-Valdivia Sergio Gonzalez-Vazquez Diana Esperanza Arevalo-Simental Jose Jorge Gomez-Camarena Juan Manuel Ponce-Guarneros Norma Alejandra Rodriguez-Jimenez Ana Miriam Saldaña-Cruz Ernesto German Cardona-Muñoz Laura Gonzalez-Lopez |
| author_facet | Aline Priscilla Santiago-Garcia Jorge Ivan Gamez-Nava Felipe Alexis Avalos-Salgado Sergio Cerpa-Cruz Edna Lizeth Amaya-Cabrera Sergio Gutierrez-Ureña Cesar Arturo Nava-Valdivia Sergio Gonzalez-Vazquez Diana Esperanza Arevalo-Simental Jose Jorge Gomez-Camarena Juan Manuel Ponce-Guarneros Norma Alejandra Rodriguez-Jimenez Ana Miriam Saldaña-Cruz Ernesto German Cardona-Muñoz Laura Gonzalez-Lopez |
| author_sort | Aline Priscilla Santiago-Garcia |
| collection | DOAJ |
| description | The use of complementary therapies is highly prevalent among patients with rheumatoid arthritis (RA). Nevertheless, the use of complementary medicine could involve problems in the following of scientifically accepted treatments. To date, there is limited information regarding the association of nonconventional therapies with problems regarding compliance with the treatment. Therefore, the objective of this study was to identify whether the utilization of complementary therapies is associated with a high risk of problems regarding therapeutic adherence to conventional synthetic disease-modifying anti-rheumatic drugs (cs-DMARDs) in RA patients. A survey was performed with RA patients in an outpatient rheumatology clinic in a university hospital; the use of complementary therapies, as well as their type, was identified. To assess problems with therapeutic adherence, we used the four-item Morisky–Green scale. A comprehensive assessment of clinical and therapeutic characteristics was performed. Univariable and multivariable models were performed to identify the risk of problems with therapeutic adherence in users of complementary therapies. In total, 250 RA patients were included; 92% used complementary therapies. Of them, the most frequently used were herbal medicine (65%), homeopathy (64%), and cannabis and its derivatives (51%). In the univariable logistic regression analysis, the factors associated with problems in the therapeutic adherence to cs-DMARDs were age (<i>p</i> = 0.019), the presence of other comorbidities (<i>p</i> = 0.047), and the use of complementary therapies (<i>p</i> = 0.042). After controlling for potential confounders, the use of complementary therapies increased the risk of problems with therapeutic adherence to cs-DMARDs (adjusted OR = 2.84, 95% CI = 1.06–7.63, <i>p</i> = 0.037). We concluded that the use of complementary therapies increases the risk of problems with therapeutic adherence. Therefore, for physicians and healthcare professionals, the early identification of the use of nonconventional therapies in their RA patients is required, followed by a directed discussion with their patients about the risks and benefits to which they could be exposed to complementary therapies. |
| first_indexed | 2024-03-08T15:06:16Z |
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| id | doaj.art-491573ba6f924ba2b1663603c1f257a4 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-08T15:06:16Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-491573ba6f924ba2b1663603c1f257a42024-01-10T14:57:24ZengMDPI AGHealthcare2227-90322023-12-011214910.3390/healthcare12010049Complementary Therapies and Their Association with Problems in Therapeutic Adherence to Conventional Synthetic DMARDs in Rheumatoid Arthritis: A Cross-Sectional StudyAline Priscilla Santiago-Garcia0Jorge Ivan Gamez-Nava1Felipe Alexis Avalos-Salgado2Sergio Cerpa-Cruz3Edna Lizeth Amaya-Cabrera4Sergio Gutierrez-Ureña5Cesar Arturo Nava-Valdivia6Sergio Gonzalez-Vazquez7Diana Esperanza Arevalo-Simental8Jose Jorge Gomez-Camarena9Juan Manuel Ponce-Guarneros10Norma Alejandra Rodriguez-Jimenez11Ana Miriam Saldaña-Cruz12Ernesto German Cardona-Muñoz13Laura Gonzalez-Lopez14Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoPrograma de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoPrograma de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoDepartamento de Reumatología, Hospital Civil Fray Antonio Alcalde, Guadalajara 45019, MexicoDepartamento de Reumatología, Hospital Civil Fray Antonio Alcalde, Guadalajara 45019, MexicoPrograma de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoDepartamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoHospital General Regional 110 Instituto Mexicano del Seguro Social, Guadalajara 44716, MexicoPrograma de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoPrograma de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoPrograma de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoPrograma de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoPrograma de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoResearch Group for Factors Related to Therapeutic Outcomes in Autoimmune Diseases, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoPrograma de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoThe use of complementary therapies is highly prevalent among patients with rheumatoid arthritis (RA). Nevertheless, the use of complementary medicine could involve problems in the following of scientifically accepted treatments. To date, there is limited information regarding the association of nonconventional therapies with problems regarding compliance with the treatment. Therefore, the objective of this study was to identify whether the utilization of complementary therapies is associated with a high risk of problems regarding therapeutic adherence to conventional synthetic disease-modifying anti-rheumatic drugs (cs-DMARDs) in RA patients. A survey was performed with RA patients in an outpatient rheumatology clinic in a university hospital; the use of complementary therapies, as well as their type, was identified. To assess problems with therapeutic adherence, we used the four-item Morisky–Green scale. A comprehensive assessment of clinical and therapeutic characteristics was performed. Univariable and multivariable models were performed to identify the risk of problems with therapeutic adherence in users of complementary therapies. In total, 250 RA patients were included; 92% used complementary therapies. Of them, the most frequently used were herbal medicine (65%), homeopathy (64%), and cannabis and its derivatives (51%). In the univariable logistic regression analysis, the factors associated with problems in the therapeutic adherence to cs-DMARDs were age (<i>p</i> = 0.019), the presence of other comorbidities (<i>p</i> = 0.047), and the use of complementary therapies (<i>p</i> = 0.042). After controlling for potential confounders, the use of complementary therapies increased the risk of problems with therapeutic adherence to cs-DMARDs (adjusted OR = 2.84, 95% CI = 1.06–7.63, <i>p</i> = 0.037). We concluded that the use of complementary therapies increases the risk of problems with therapeutic adherence. Therefore, for physicians and healthcare professionals, the early identification of the use of nonconventional therapies in their RA patients is required, followed by a directed discussion with their patients about the risks and benefits to which they could be exposed to complementary therapies.https://www.mdpi.com/2227-9032/12/1/49rheumatoid arthritiscomplementary therapiesconventional synthetic disease modifying anti-rheumatic drugstherapeutic adherencesMorisky–Green scalecross-sectional study |
| spellingShingle | Aline Priscilla Santiago-Garcia Jorge Ivan Gamez-Nava Felipe Alexis Avalos-Salgado Sergio Cerpa-Cruz Edna Lizeth Amaya-Cabrera Sergio Gutierrez-Ureña Cesar Arturo Nava-Valdivia Sergio Gonzalez-Vazquez Diana Esperanza Arevalo-Simental Jose Jorge Gomez-Camarena Juan Manuel Ponce-Guarneros Norma Alejandra Rodriguez-Jimenez Ana Miriam Saldaña-Cruz Ernesto German Cardona-Muñoz Laura Gonzalez-Lopez Complementary Therapies and Their Association with Problems in Therapeutic Adherence to Conventional Synthetic DMARDs in Rheumatoid Arthritis: A Cross-Sectional Study Healthcare rheumatoid arthritis complementary therapies conventional synthetic disease modifying anti-rheumatic drugs therapeutic adherences Morisky–Green scale cross-sectional study |
| title | Complementary Therapies and Their Association with Problems in Therapeutic Adherence to Conventional Synthetic DMARDs in Rheumatoid Arthritis: A Cross-Sectional Study |
| title_full | Complementary Therapies and Their Association with Problems in Therapeutic Adherence to Conventional Synthetic DMARDs in Rheumatoid Arthritis: A Cross-Sectional Study |
| title_fullStr | Complementary Therapies and Their Association with Problems in Therapeutic Adherence to Conventional Synthetic DMARDs in Rheumatoid Arthritis: A Cross-Sectional Study |
| title_full_unstemmed | Complementary Therapies and Their Association with Problems in Therapeutic Adherence to Conventional Synthetic DMARDs in Rheumatoid Arthritis: A Cross-Sectional Study |
| title_short | Complementary Therapies and Their Association with Problems in Therapeutic Adherence to Conventional Synthetic DMARDs in Rheumatoid Arthritis: A Cross-Sectional Study |
| title_sort | complementary therapies and their association with problems in therapeutic adherence to conventional synthetic dmards in rheumatoid arthritis a cross sectional study |
| topic | rheumatoid arthritis complementary therapies conventional synthetic disease modifying anti-rheumatic drugs therapeutic adherences Morisky–Green scale cross-sectional study |
| url | https://www.mdpi.com/2227-9032/12/1/49 |
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