Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties
Biologically active peptides have been attracting increasing attention, whether to improve the understanding of their mechanisms of action or in the search for new therapeutic drugs. Wasp venoms have been explored as a remarkable source for these molecules. In this review, the main findings on the g...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.824989/full |
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| author | Carlos José Correia de Santana Carlos José Correia de Santana Osmindo Rodrigues Pires Júnior Wagner Fontes Mário Sérgio Palma Mariana S. Castro Mariana S. Castro |
| author_facet | Carlos José Correia de Santana Carlos José Correia de Santana Osmindo Rodrigues Pires Júnior Wagner Fontes Mário Sérgio Palma Mariana S. Castro Mariana S. Castro |
| author_sort | Carlos José Correia de Santana |
| collection | DOAJ |
| description | Biologically active peptides have been attracting increasing attention, whether to improve the understanding of their mechanisms of action or in the search for new therapeutic drugs. Wasp venoms have been explored as a remarkable source for these molecules. In this review, the main findings on the group of wasp linear cationic α-helical peptides called mastoparans were discussed. These compounds have a wide variety of biological effects, including mast cell degranulation, activation of protein G, phospholipase A2, C, and D activation, serotonin and insulin release, and antimicrobial, hemolytic, and anticancer activities, which could lead to the development of new therapeutic agents. |
| first_indexed | 2024-04-12T12:04:27Z |
| format | Article |
| id | doaj.art-4916048307f241969cfbaca242863b2b |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-12T12:04:27Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-4916048307f241969cfbaca242863b2b2022-12-22T03:33:44ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-06-01910.3389/fmolb.2022.824989824989Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic PropertiesCarlos José Correia de Santana0Carlos José Correia de Santana1Osmindo Rodrigues Pires Júnior2Wagner Fontes3Mário Sérgio Palma4Mariana S. Castro5Mariana S. Castro6Laboratory of Toxinology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, BrazilLaboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, BrazilLaboratory of Toxinology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, BrazilLaboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, BrazilDepartment of Basic and Applied Biology, Institute of Biosciences of Rio Claro, São Paulo State University, UNESP, Rio Claro, BrazilLaboratory of Toxinology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, BrazilLaboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, BrazilBiologically active peptides have been attracting increasing attention, whether to improve the understanding of their mechanisms of action or in the search for new therapeutic drugs. Wasp venoms have been explored as a remarkable source for these molecules. In this review, the main findings on the group of wasp linear cationic α-helical peptides called mastoparans were discussed. These compounds have a wide variety of biological effects, including mast cell degranulation, activation of protein G, phospholipase A2, C, and D activation, serotonin and insulin release, and antimicrobial, hemolytic, and anticancer activities, which could lead to the development of new therapeutic agents.https://www.frontiersin.org/articles/10.3389/fmolb.2022.824989/fullsocial and solitary waspsvenomlinear cationic α-helical peptidemastoparansmast cell degranulationantimicrobial peptide |
| spellingShingle | Carlos José Correia de Santana Carlos José Correia de Santana Osmindo Rodrigues Pires Júnior Wagner Fontes Mário Sérgio Palma Mariana S. Castro Mariana S. Castro Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties Frontiers in Molecular Biosciences social and solitary wasps venom linear cationic α-helical peptide mastoparans mast cell degranulation antimicrobial peptide |
| title | Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties |
| title_full | Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties |
| title_fullStr | Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties |
| title_full_unstemmed | Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties |
| title_short | Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties |
| title_sort | mastoparans a group of multifunctional α helical peptides with promising therapeutic properties |
| topic | social and solitary wasps venom linear cationic α-helical peptide mastoparans mast cell degranulation antimicrobial peptide |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.824989/full |
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