Application of PROTACs in target identification and validation
Proteolysis targeting chimeras (PROTACs), as a novel therapeutic drug model, has received widespread attention from academia and the pharmaceutical industry. PROTAC technology has led researchers to focus on developing chemical biology tool properties due to the unique operating mechanism and protei...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2024-03-01
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| Series: | Acta Materia Medica |
| Subjects: | |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0010 |
| _version_ | 1827309703751794688 |
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| author | Yang Liu Jing Liang Rui Zhu Yueying Yang Yali Wang Wenyi Wei Hua Li Lixia Chen |
| author_facet | Yang Liu Jing Liang Rui Zhu Yueying Yang Yali Wang Wenyi Wei Hua Li Lixia Chen |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Proteolysis targeting chimeras (PROTACs), as a novel therapeutic drug model, has received widespread attention from academia and the pharmaceutical industry. PROTAC technology has led researchers to focus on developing chemical biology tool properties due to the unique operating mechanism and protein dynamic regulatory properties. In recent years the rapid development of PROTAC technology has gradually made PROTACs an essential tool for target identification and validation. To further promote the application of PROTAC tools in drug discovery and basic medical science research, this review distinguished target identification and validation concepts. Furthermore, research progress in PROTAC technology was summarized. |
| first_indexed | 2024-04-24T19:46:09Z |
| format | Article |
| id | doaj.art-49164456b0c248869c940995b8c087ec |
| institution | Directory Open Access Journal |
| issn | 2737-7946 |
| language | English |
| last_indexed | 2024-04-24T19:46:09Z |
| publishDate | 2024-03-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj.art-49164456b0c248869c940995b8c087ec2024-03-25T05:39:16ZengCompuscript LtdActa Materia Medica2737-79462024-03-0131728710.15212/AMM-2024-0010Application of PROTACs in target identification and validationYang Liu0Jing Liang1Rui Zhu2Yueying Yang3Yali Wang4Wenyi Wei5Hua Li6Lixia Chen7Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, ChinaWuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, ChinaWuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, ChinaWuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, ChinaInstitute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USAWuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, ChinaWuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, ChinaProteolysis targeting chimeras (PROTACs), as a novel therapeutic drug model, has received widespread attention from academia and the pharmaceutical industry. PROTAC technology has led researchers to focus on developing chemical biology tool properties due to the unique operating mechanism and protein dynamic regulatory properties. In recent years the rapid development of PROTAC technology has gradually made PROTACs an essential tool for target identification and validation. To further promote the application of PROTAC tools in drug discovery and basic medical science research, this review distinguished target identification and validation concepts. Furthermore, research progress in PROTAC technology was summarized.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0010protacprobetarget identificationtarget validation |
| spellingShingle | Yang Liu Jing Liang Rui Zhu Yueying Yang Yali Wang Wenyi Wei Hua Li Lixia Chen Application of PROTACs in target identification and validation Acta Materia Medica protac probe target identification target validation |
| title | Application of PROTACs in target identification and validation |
| title_full | Application of PROTACs in target identification and validation |
| title_fullStr | Application of PROTACs in target identification and validation |
| title_full_unstemmed | Application of PROTACs in target identification and validation |
| title_short | Application of PROTACs in target identification and validation |
| title_sort | application of protacs in target identification and validation |
| topic | protac probe target identification target validation |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0010 |
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