Knockout of Sirt2 alleviates traumatic brain injury in mice

Knockout of Sirt2 alleviates traumatic brain injury in mice

Sirtuin 2 (SIRT2) inhibition or Sirt2 knockout in animal models protects against the development of neurodegenerative diseases and cerebral ischemia. However, the role of SIRT2 in traumatic brain injury (TBI) remains unclear. In this study, we found that knockout of Sirt2 in a mouse model of TBI red...

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Bibliographic Details
Main Authors:	Wei Wang, Qiu-Yuan Gong, Lin Cai, Yao Jing, Dian-Xu Yang, Fang Yuan, Hao Chen, Heng-Li Tian
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2023-01-01
Series:	Neural Regeneration Research
Subjects:	blood-brain barrier; caspase-1; cerebral edema; neuroinflammation; neuroprotection; nlrp3; pyroptosis; sirt2; tight junction protein; traumatic brain injury
Online Access:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=350;epage=356;aulast=

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