Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment
IntroductionFood sensitization is a first and strong indicator of immune deviation in the progression to other allergic conditions. Sensitization to food or other allergens and related inflammation during critical windows of infant development may adversely affect neurodevelopmental milestones. Howe...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.734428/full |
| _version_ | 1797989758851350528 |
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| author | Nicole Rodriguez Carmen A. Tessier Piushkumar J. Mandhane Jacqueline Pei Elinor Simons Theo J. Moraes Stuart E. Turvey Padmaja Subbarao Anita L. Kozyrskyj Anita L. Kozyrskyj |
| author_facet | Nicole Rodriguez Carmen A. Tessier Piushkumar J. Mandhane Jacqueline Pei Elinor Simons Theo J. Moraes Stuart E. Turvey Padmaja Subbarao Anita L. Kozyrskyj Anita L. Kozyrskyj |
| author_sort | Nicole Rodriguez |
| collection | DOAJ |
| description | IntroductionFood sensitization is a first and strong indicator of immune deviation in the progression to other allergic conditions. Sensitization to food or other allergens and related inflammation during critical windows of infant development may adversely affect neurodevelopmental milestones. However, additional research is needed to test this association further.MethodsAssociations between atopic (any food or aeroallergen) or food sensitization (specific to egg, soybean, peanut, and milk) at age 1 year and neurodevelopment up to 2 years of age were evaluated in the national CHILD Cohort Study, with a secondary aim examining whether these associations were sex-specific. Food and atopic sensitization were assessed by skin prick tests (SPT) in 1-year-old infants, with neurodevelopment assessed using the cognitive, language, motor, and social-emotional subscales of the Bayley Scales of Infant Development (BSID-III) administered at 1 and 2 years of age.ResultsAtopic sensitization was present among 16.4% of infants, while 13.4% had food sensitizations. Only socioemotional scores reached statistical significance among the four BSID-III domains. Both atopic and food sensitization at 1 year of age was associated with lower social-emotional scores, independent of the infant's ethnicity. These findings were sex-specific and only observed among boys, among whom social-emotional scores were lowered by 5 points if atopic sensitization was present (−5.22 [95% CI: −9.96, −0.47], p = 0.03) or if food sensitization was present (−4.85 [95% CI: −9.82,0.11], p = 0.06). Similar results were observed using the standard SPT cut-off of ≥3 mm — for atopic sensitization (−5.17 [95% CI: −11.14, −0.80], p = 0.09) and for food sensitization (−4.61 [95% CI: −10.96, 1.74], p = 0.15).ConclusionIn our study of term infants, we found an inverse, cross-sectional association between atopic and food sensitization status and social-emotional development scores in male children but not female children. |
| first_indexed | 2024-04-11T08:25:29Z |
| format | Article |
| id | doaj.art-491a8d7e152c47929b79817cc04b37e1 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-11T08:25:29Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-491a8d7e152c47929b79817cc04b37e12022-12-22T04:34:47ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-09-011010.3389/fped.2022.734428734428Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopmentNicole Rodriguez0Carmen A. Tessier1Piushkumar J. Mandhane2Jacqueline Pei3Elinor Simons4Theo J. Moraes5Stuart E. Turvey6Padmaja Subbarao7Anita L. Kozyrskyj8Anita L. Kozyrskyj9Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, CanadaDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, CanadaDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, CanadaDepartment of Educational Psychology, Faculty of Education, University of Alberta, Edmonton, AB, CanadaDepartment of Pediatrics and Child Health, University of Manitoba and Children's Hospital Research Institute of Manitoba, Winnipeg, MB, CanadaDepartment of Pediatrics, Faculty of Medicine, University of Toronto and Hospital for Sick Children, Toronto, ON, CanadaDepartment of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, CanadaDepartment of Pediatrics, Faculty of Medicine, University of Toronto and Hospital for Sick Children, Toronto, ON, CanadaDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, CanadaDepartment of Obstetrics and Gynecology, School of Public Health, University of Alberta, Edmonton, AB, CanadaIntroductionFood sensitization is a first and strong indicator of immune deviation in the progression to other allergic conditions. Sensitization to food or other allergens and related inflammation during critical windows of infant development may adversely affect neurodevelopmental milestones. However, additional research is needed to test this association further.MethodsAssociations between atopic (any food or aeroallergen) or food sensitization (specific to egg, soybean, peanut, and milk) at age 1 year and neurodevelopment up to 2 years of age were evaluated in the national CHILD Cohort Study, with a secondary aim examining whether these associations were sex-specific. Food and atopic sensitization were assessed by skin prick tests (SPT) in 1-year-old infants, with neurodevelopment assessed using the cognitive, language, motor, and social-emotional subscales of the Bayley Scales of Infant Development (BSID-III) administered at 1 and 2 years of age.ResultsAtopic sensitization was present among 16.4% of infants, while 13.4% had food sensitizations. Only socioemotional scores reached statistical significance among the four BSID-III domains. Both atopic and food sensitization at 1 year of age was associated with lower social-emotional scores, independent of the infant's ethnicity. These findings were sex-specific and only observed among boys, among whom social-emotional scores were lowered by 5 points if atopic sensitization was present (−5.22 [95% CI: −9.96, −0.47], p = 0.03) or if food sensitization was present (−4.85 [95% CI: −9.82,0.11], p = 0.06). Similar results were observed using the standard SPT cut-off of ≥3 mm — for atopic sensitization (−5.17 [95% CI: −11.14, −0.80], p = 0.09) and for food sensitization (−4.61 [95% CI: −10.96, 1.74], p = 0.15).ConclusionIn our study of term infants, we found an inverse, cross-sectional association between atopic and food sensitization status and social-emotional development scores in male children but not female children.https://www.frontiersin.org/articles/10.3389/fped.2022.734428/fullfood sensitizationatopic sensitizationatopyinfantneurodevelopmentsocial- emotional infant sensitizations and socio-emotional development |
| spellingShingle | Nicole Rodriguez Carmen A. Tessier Piushkumar J. Mandhane Jacqueline Pei Elinor Simons Theo J. Moraes Stuart E. Turvey Padmaja Subbarao Anita L. Kozyrskyj Anita L. Kozyrskyj Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment Frontiers in Pediatrics food sensitization atopic sensitization atopy infant neurodevelopment social- emotional infant sensitizations and socio-emotional development |
| title | Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment |
| title_full | Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment |
| title_fullStr | Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment |
| title_full_unstemmed | Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment |
| title_short | Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment |
| title_sort | sex specific associations among infant food and atopic sensitizations and infant neurodevelopment |
| topic | food sensitization atopic sensitization atopy infant neurodevelopment social- emotional infant sensitizations and socio-emotional development |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.734428/full |
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