Exosome: A New Player in Translational Nanomedicine
Summary: Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Two main functions have been attributed to exosomes: their capacity to transport proteins, lipids and...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/9/8/2380 |
| _version_ | 1797561296917364736 |
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| author | Houssam Aheget María Tristán-Manzano Loubna Mazini Marina Cortijo-Gutierrez Pablo Galindo-Moreno Concha Herrera Francisco Martin Juan Antonio Marchal Karim Benabdellah |
| author_facet | Houssam Aheget María Tristán-Manzano Loubna Mazini Marina Cortijo-Gutierrez Pablo Galindo-Moreno Concha Herrera Francisco Martin Juan Antonio Marchal Karim Benabdellah |
| author_sort | Houssam Aheget |
| collection | DOAJ |
| description | Summary: Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Two main functions have been attributed to exosomes: their capacity to transport proteins, lipids and nucleic acids between cells and organs, as well as their potential to act as natural intercellular communicators in normal biological processes and in pathologies. From a clinical perspective, the majority of applications use exosomes as biomarkers of disease. A new approach uses exosomes as biologically active carriers to provide a platform for the enhanced delivery of cargo in vivo. One of the major limitations in developing exosome-based therapies is the difficulty of producing sufficient amounts of safe and efficient exosomes. The identification of potential proteins involved in exosome biogenesis is expected to directly cause a deliberate increase in exosome production. In this review, we summarize the current state of knowledge regarding exosomes, with particular emphasis on their structural features, biosynthesis pathways, production techniques and potential clinical applications. |
| first_indexed | 2024-03-10T18:11:54Z |
| format | Article |
| id | doaj.art-491c0a50ea4f4517b943ef9244ab9634 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:11:54Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-491c0a50ea4f4517b943ef9244ab96342023-11-20T07:58:59ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0198238010.3390/jcm9082380Exosome: A New Player in Translational NanomedicineHoussam Aheget0María Tristán-Manzano1Loubna Mazini2Marina Cortijo-Gutierrez3Pablo Galindo-Moreno4Concha Herrera5Francisco Martin6Juan Antonio Marchal7Karim Benabdellah8Genomic Medicine Department, GENYO, Centre for Genomics and Oncological Research, Pfizer-University of Granada (Andalusian Regional Government), Health Sciences Technology Park, Av. de la Illustration 114, 18016 Granada, SpainGenomic Medicine Department, GENYO, Centre for Genomics and Oncological Research, Pfizer-University of Granada (Andalusian Regional Government), Health Sciences Technology Park, Av. de la Illustration 114, 18016 Granada, SpainMedical Application Interface Center, Mohammed VI Polytechnic University, 43152 Ben-Guerir, MoroccoGenomic Medicine Department, GENYO, Centre for Genomics and Oncological Research, Pfizer-University of Granada (Andalusian Regional Government), Health Sciences Technology Park, Av. de la Illustration 114, 18016 Granada, SpainOral Surgery and Implant Dentistry Department, School of Dentistry, University of Granada, 18011 Granada, SpainMaimonides Institute of Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, SpainGenomic Medicine Department, GENYO, Centre for Genomics and Oncological Research, Pfizer-University of Granada (Andalusian Regional Government), Health Sciences Technology Park, Av. de la Illustration 114, 18016 Granada, SpainBiomedical Research Institute, ibs. Granada, 18012 Granada, SpainGenomic Medicine Department, GENYO, Centre for Genomics and Oncological Research, Pfizer-University of Granada (Andalusian Regional Government), Health Sciences Technology Park, Av. de la Illustration 114, 18016 Granada, SpainSummary: Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Two main functions have been attributed to exosomes: their capacity to transport proteins, lipids and nucleic acids between cells and organs, as well as their potential to act as natural intercellular communicators in normal biological processes and in pathologies. From a clinical perspective, the majority of applications use exosomes as biomarkers of disease. A new approach uses exosomes as biologically active carriers to provide a platform for the enhanced delivery of cargo in vivo. One of the major limitations in developing exosome-based therapies is the difficulty of producing sufficient amounts of safe and efficient exosomes. The identification of potential proteins involved in exosome biogenesis is expected to directly cause a deliberate increase in exosome production. In this review, we summarize the current state of knowledge regarding exosomes, with particular emphasis on their structural features, biosynthesis pathways, production techniques and potential clinical applications.https://www.mdpi.com/2077-0383/9/8/2380immunotherapyexosomesCARsgene editingcancerliquid biopsies |
| spellingShingle | Houssam Aheget María Tristán-Manzano Loubna Mazini Marina Cortijo-Gutierrez Pablo Galindo-Moreno Concha Herrera Francisco Martin Juan Antonio Marchal Karim Benabdellah Exosome: A New Player in Translational Nanomedicine Journal of Clinical Medicine immunotherapy exosomes CARs gene editing cancer liquid biopsies |
| title | Exosome: A New Player in Translational Nanomedicine |
| title_full | Exosome: A New Player in Translational Nanomedicine |
| title_fullStr | Exosome: A New Player in Translational Nanomedicine |
| title_full_unstemmed | Exosome: A New Player in Translational Nanomedicine |
| title_short | Exosome: A New Player in Translational Nanomedicine |
| title_sort | exosome a new player in translational nanomedicine |
| topic | immunotherapy exosomes CARs gene editing cancer liquid biopsies |
| url | https://www.mdpi.com/2077-0383/9/8/2380 |
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