Effects of changing the timing of warfarin administration in combination with fluconazole on prolongation of the PT-INR: a case report

Effects of changing the timing of warfarin administration in combination with fluconazole on prolongation of the PT-INR: a case report

Abstract Background Fluconazole (FLCZ) inhibits cytochrome P450 (CYP) 2C9, 2C19, and 3A4 and has a drug-drug interaction that potentiates the effects of warfarin and prolong the prothrombin time-international normalized ratio (PT-INR). Although a drug-drug interaction have been reported between FLCZ...

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Bibliographic Details
Main Authors: Hayato Akamatsu, Hiroo Nakagawa, Ichiro Matsumaru, Junya Hashizume, Hitomi Harasawa, Yukinobu Kodama, Takashi Miura, Kaname Ohyama
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Fluconazole
Warfarin
PT-INR
Drug-drug interaction
Timing of administration
Online Access:https://doi.org/10.1186/s40780-023-00279-w

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