Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.

Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.

Serine protease granzyme B plays important roles in infections, autoimmunity, transplant rejection, and antitumor immunity. A triple-mutated granzyme B variant that encodes three amino substitutions (Q48R, P88A, and Y245H) has been reported to have altered biological functions. In the polymorphism r...

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Bibliographic Details
Main Authors: Luis J Espinoza, Akiyoshi Takami, Katsuya Nakata, Kayoko Yamada, Makoto Onizuka, Takakazu Kawase, Hiroshi Sao, Hideki Akiyama, Koichi Miyamura, Shinichiro Okamoto, Masami Inoue, Takahiro Fukuda, Yasuo Morishima, Yoshihisa Kodera, Shinji Nakao, Japan Marrow Donor Program
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21886827/?tool=EBI

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