IMMOBILIZATION OF ANTITUMOR DRUGS ON NANOPARTICLES
Literature data and the results of the authors regarding the immobilization of traditional anticancer drugs on nanoparticles (e.g., by use of non-covalent binding, physical adsorption) with the aim of the targeted delivery of these anticancer agents and enhance their therapeutic actions have been an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2015-04-01
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| Series: | Biotechnologia Acta |
| Subjects: | |
| Online Access: | http://biotechnology.kiev.ua/images/no2_2015/prilutskii.pdf |
| _version_ | 1797728061314039808 |
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| author | Yu. I. Prylutskyy М. А. Zabolotnyy G. I. Solyanyk L. M. Kirkilevskaya |
| author_facet | Yu. I. Prylutskyy М. А. Zabolotnyy G. I. Solyanyk L. M. Kirkilevskaya |
| author_sort | Yu. I. Prylutskyy |
| collection | DOAJ |
| description | Literature data and the results of the authors regarding the immobilization of traditional anticancer drugs on nanoparticles (e.g., by use of non-covalent binding, physical adsorption) with the aim of the targeted delivery of these anticancer agents and enhance their therapeutic actions have been analyzed. The physical aspects of these particles (e.g., size effect, specific surface energy), which should be taken into account for achieving their biocompatibility with the cells and tissues of the body have been discussed. It was indicated that irradiation of different nature (e.g., light, low energy electrons) can also be used to transfer molecules of medicals into a metastable state with their subsequent conversion into a state with increased pharmacological activity in immobilization on nanoparticles. |
| first_indexed | 2024-03-12T11:08:26Z |
| format | Article |
| id | doaj.art-492280daac96438c938a0e1d6565b0fa |
| institution | Directory Open Access Journal |
| issn | 2410-7751 2410-776X |
| language | English |
| last_indexed | 2024-03-12T11:08:26Z |
| publishDate | 2015-04-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | Biotechnologia Acta |
| spelling | doaj.art-492280daac96438c938a0e1d6565b0fa2023-09-02T03:15:18ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryBiotechnologia Acta2410-77512410-776X2015-04-018210711110.15407/biotech8.02.107IMMOBILIZATION OF ANTITUMOR DRUGS ON NANOPARTICLESYu. I. Prylutskyy0М. А. Zabolotnyy1G. I. Solyanyk2 L. M. Kirkilevskaya3Taras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineKavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, KyivKavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, KyivLiterature data and the results of the authors regarding the immobilization of traditional anticancer drugs on nanoparticles (e.g., by use of non-covalent binding, physical adsorption) with the aim of the targeted delivery of these anticancer agents and enhance their therapeutic actions have been analyzed. The physical aspects of these particles (e.g., size effect, specific surface energy), which should be taken into account for achieving their biocompatibility with the cells and tissues of the body have been discussed. It was indicated that irradiation of different nature (e.g., light, low energy electrons) can also be used to transfer molecules of medicals into a metastable state with their subsequent conversion into a state with increased pharmacological activity in immobilization on nanoparticles.http://biotechnology.kiev.ua/images/no2_2015/prilutskii.pdfanticancer drugsnanoparticlesimmobilization |
| spellingShingle | Yu. I. Prylutskyy М. А. Zabolotnyy G. I. Solyanyk L. M. Kirkilevskaya IMMOBILIZATION OF ANTITUMOR DRUGS ON NANOPARTICLES Biotechnologia Acta anticancer drugs nanoparticles immobilization |
| title | IMMOBILIZATION OF ANTITUMOR DRUGS ON NANOPARTICLES |
| title_full | IMMOBILIZATION OF ANTITUMOR DRUGS ON NANOPARTICLES |
| title_fullStr | IMMOBILIZATION OF ANTITUMOR DRUGS ON NANOPARTICLES |
| title_full_unstemmed | IMMOBILIZATION OF ANTITUMOR DRUGS ON NANOPARTICLES |
| title_short | IMMOBILIZATION OF ANTITUMOR DRUGS ON NANOPARTICLES |
| title_sort | immobilization of antitumor drugs on nanoparticles |
| topic | anticancer drugs nanoparticles immobilization |
| url | http://biotechnology.kiev.ua/images/no2_2015/prilutskii.pdf |
| work_keys_str_mv | AT yuiprylutskyy immobilizationofantitumordrugsonnanoparticles AT mazabolotnyy immobilizationofantitumordrugsonnanoparticles AT gisolyanyk immobilizationofantitumordrugsonnanoparticles AT lmkirkilevskaya immobilizationofantitumordrugsonnanoparticles |