Research Progress of Microbiota-Gut-Brain Axis in Parkinson's Disease
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by misfolding of α-synuclein. Clinical manifestations include slowly developing resting tremor, muscle rigidity, bradykinesia and abnormal gait. The pathological mechanisms underlying PD are complex and yet to be fully elu...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2023-10-01
|
| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206157 |
| _version_ | 1827390583429136384 |
|---|---|
| author | Wei Zhang Yalin Ye Jiayang Song Tian Sang Tingting Xia Linhong Xie Xiaofei Qiu Qijing Zeng Xin Luo |
| author_facet | Wei Zhang Yalin Ye Jiayang Song Tian Sang Tingting Xia Linhong Xie Xiaofei Qiu Qijing Zeng Xin Luo |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by misfolding of α-synuclein. Clinical manifestations include slowly developing resting tremor, muscle rigidity, bradykinesia and abnormal gait. The pathological mechanisms underlying PD are complex and yet to be fully elucidated. Clinical studies suggest that the onset of gastrointestinal symptoms may precede motor symptoms in PD patients. The microbiota-gut-brain axis plays a bidirectional communication role between the enteric nervous system and the central nervous system. This bidirectional communication between the brain and gut is influenced by the neural, immune and endocrine systems related to the gut microbiome. A growing body of evidence indicates a strong link between dysregulation of the gut microbiota and PD. In this review, we present recent progress in understanding the relationship between the microbiota-gut-brain axis and PD. We focus on the role of the gut microbiota, the unique changes observed in the microbiome of PD patients, and the impact of these changes on the progression of PD. Finally, we evaluate the role of current treatment strategies for PD, including probiotics, fecal microbial transplants, dietary modifications, and related drug therapies. |
| first_indexed | 2024-03-08T16:54:49Z |
| format | Article |
| id | doaj.art-49238d37d00b4672aa04163f93a86401 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-03-08T16:54:49Z |
| publishDate | 2023-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-49238d37d00b4672aa04163f93a864012024-01-05T02:39:08ZengIMR PressJournal of Integrative Neuroscience0219-63522023-10-0122615710.31083/j.jin2206157S0219-6352(23)00593-4Research Progress of Microbiota-Gut-Brain Axis in Parkinson's DiseaseWei Zhang0Yalin Ye1Jiayang Song2Tian Sang3Tingting Xia4Linhong Xie5Xiaofei Qiu6Qijing Zeng7Xin Luo8Department of Pharmacy, The People's Hospital of Kaizhou District, 405400 Chongqing, ChinaDepartment of Pharmacy, Chengdu Second People's Hospital, 610017 Chengdu, Sichuan, ChinaDepartment of Pharmacy, Cangxi People's Hospital, 628400 Nanchong, Sichuan, ChinaDepartment of Pharmacy, The People's Hospital of Kaizhou District, 405400 Chongqing, ChinaDepartment of Pharmacy, The People's Hospital of Kaizhou District, 405400 Chongqing, ChinaDepartment of Pharmacy, The People's Hospital of Kaizhou District, 405400 Chongqing, ChinaDepartment of Pharmacy, The People's Hospital of Kaizhou District, 405400 Chongqing, ChinaDepartment of Pharmacy, The People's Hospital of Kaizhou District, 405400 Chongqing, ChinaDepartment of Gastroenterology, The People's Hospital of Kaizhou District, 405400 Chongqing, ChinaParkinson’s disease (PD) is a common neurodegenerative disorder characterized by misfolding of α-synuclein. Clinical manifestations include slowly developing resting tremor, muscle rigidity, bradykinesia and abnormal gait. The pathological mechanisms underlying PD are complex and yet to be fully elucidated. Clinical studies suggest that the onset of gastrointestinal symptoms may precede motor symptoms in PD patients. The microbiota-gut-brain axis plays a bidirectional communication role between the enteric nervous system and the central nervous system. This bidirectional communication between the brain and gut is influenced by the neural, immune and endocrine systems related to the gut microbiome. A growing body of evidence indicates a strong link between dysregulation of the gut microbiota and PD. In this review, we present recent progress in understanding the relationship between the microbiota-gut-brain axis and PD. We focus on the role of the gut microbiota, the unique changes observed in the microbiome of PD patients, and the impact of these changes on the progression of PD. Finally, we evaluate the role of current treatment strategies for PD, including probiotics, fecal microbial transplants, dietary modifications, and related drug therapies.https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206157parkinson's diseasemicrobiota-gut-brain axisgut microbiomegut microbiota intervention |
| spellingShingle | Wei Zhang Yalin Ye Jiayang Song Tian Sang Tingting Xia Linhong Xie Xiaofei Qiu Qijing Zeng Xin Luo Research Progress of Microbiota-Gut-Brain Axis in Parkinson's Disease Journal of Integrative Neuroscience parkinson's disease microbiota-gut-brain axis gut microbiome gut microbiota intervention |
| title | Research Progress of Microbiota-Gut-Brain Axis in Parkinson's Disease |
| title_full | Research Progress of Microbiota-Gut-Brain Axis in Parkinson's Disease |
| title_fullStr | Research Progress of Microbiota-Gut-Brain Axis in Parkinson's Disease |
| title_full_unstemmed | Research Progress of Microbiota-Gut-Brain Axis in Parkinson's Disease |
| title_short | Research Progress of Microbiota-Gut-Brain Axis in Parkinson's Disease |
| title_sort | research progress of microbiota gut brain axis in parkinson s disease |
| topic | parkinson's disease microbiota-gut-brain axis gut microbiome gut microbiota intervention |
| url | https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206157 |
| work_keys_str_mv | AT weizhang researchprogressofmicrobiotagutbrainaxisinparkinsonsdisease AT yalinye researchprogressofmicrobiotagutbrainaxisinparkinsonsdisease AT jiayangsong researchprogressofmicrobiotagutbrainaxisinparkinsonsdisease AT tiansang researchprogressofmicrobiotagutbrainaxisinparkinsonsdisease AT tingtingxia researchprogressofmicrobiotagutbrainaxisinparkinsonsdisease AT linhongxie researchprogressofmicrobiotagutbrainaxisinparkinsonsdisease AT xiaofeiqiu researchprogressofmicrobiotagutbrainaxisinparkinsonsdisease AT qijingzeng researchprogressofmicrobiotagutbrainaxisinparkinsonsdisease AT xinluo researchprogressofmicrobiotagutbrainaxisinparkinsonsdisease |