Role of CD147 in the development and diagnosis of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1149931/full |
| _version_ | 1797851426535243776 |
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| author | Defa Huang Dingyu Rao Qing Jin Mi Lai Jiali Zhang Zhonghong Lai Haibin Shen Tianyu Zhong Tianyu Zhong |
| author_facet | Defa Huang Dingyu Rao Qing Jin Mi Lai Jiali Zhang Zhonghong Lai Haibin Shen Tianyu Zhong Tianyu Zhong |
| author_sort | Defa Huang |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and progression is imperative to development of effective diagnostic and therapeutic strategies. CD147 is a glycoprotein that is involved in tumor cell invasion, metastasis and angiogenesis through multiple mechanisms. In this review, we describe the molecular structure of CD147 and its role in regulating HCC invasion, metastasis and angiogenesis. We highlight its potential as a diagnostic and therapeutic target for HCC. |
| first_indexed | 2024-04-09T19:16:43Z |
| format | Article |
| id | doaj.art-4923f1f3cbe1433b96b4acc4e13d97d1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T19:16:43Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4923f1f3cbe1433b96b4acc4e13d97d12023-04-06T04:31:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11499311149931Role of CD147 in the development and diagnosis of hepatocellular carcinomaDefa Huang0Dingyu Rao1Qing Jin2Mi Lai3Jiali Zhang4Zhonghong Lai5Haibin Shen6Tianyu Zhong7Tianyu Zhong8Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaDepartment of traumatology, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaPrecision Medicine Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaHepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and progression is imperative to development of effective diagnostic and therapeutic strategies. CD147 is a glycoprotein that is involved in tumor cell invasion, metastasis and angiogenesis through multiple mechanisms. In this review, we describe the molecular structure of CD147 and its role in regulating HCC invasion, metastasis and angiogenesis. We highlight its potential as a diagnostic and therapeutic target for HCC.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1149931/fullhepatocellular carcinomaCD147metastasisangiogenesisdiagnosis |
| spellingShingle | Defa Huang Dingyu Rao Qing Jin Mi Lai Jiali Zhang Zhonghong Lai Haibin Shen Tianyu Zhong Tianyu Zhong Role of CD147 in the development and diagnosis of hepatocellular carcinoma Frontiers in Immunology hepatocellular carcinoma CD147 metastasis angiogenesis diagnosis |
| title | Role of CD147 in the development and diagnosis of hepatocellular carcinoma |
| title_full | Role of CD147 in the development and diagnosis of hepatocellular carcinoma |
| title_fullStr | Role of CD147 in the development and diagnosis of hepatocellular carcinoma |
| title_full_unstemmed | Role of CD147 in the development and diagnosis of hepatocellular carcinoma |
| title_short | Role of CD147 in the development and diagnosis of hepatocellular carcinoma |
| title_sort | role of cd147 in the development and diagnosis of hepatocellular carcinoma |
| topic | hepatocellular carcinoma CD147 metastasis angiogenesis diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1149931/full |
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