Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells
Activated microglial cells release various mediators, which cause neuronal cell death and have been implicated in different neurological disorders. The present study demonstrates that an infusion prepared from the plant Pulicaria incisa (Pi) inhibits microglial activation and down-regulates levels o...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-08-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464616301323 |
| _version_ | 1818596536927387648 |
|---|---|
| author | Anat Elmann Elie Beit-Yannai Alona Telerman Rivka Ofir Sharon Mordechay Hilla Erlank Hamutal Borochov-Neori |
| author_facet | Anat Elmann Elie Beit-Yannai Alona Telerman Rivka Ofir Sharon Mordechay Hilla Erlank Hamutal Borochov-Neori |
| author_sort | Anat Elmann |
| collection | DOAJ |
| description | Activated microglial cells release various mediators, which cause neuronal cell death and have been implicated in different neurological disorders. The present study demonstrates that an infusion prepared from the plant Pulicaria incisa (Pi) inhibits microglial activation and down-regulates levels of the inflammatory cytokines interleukin (IL)-1β, IL-6, and of the toxic mediators nitric oxide and glutamate. The infusion was also shown to have antioxidant properties in cell-free assays (e.g., differential pulse voltammetry) and in a cellular assay, in which the infusion attenuated the induced accumulation of intracellular reactive oxygen species (ROS). We found that Pi infusion is rich in polyphenols, especially chlorogenic acids and ferulic acids, which might be responsible for the observed activities. It is proposed that Pi infusion be further evaluated for use as a functional beverage for the prevention and/or treatment of chronic diseases, especially neurodegenerative disorders in which microglial activation and oxidative stress play important roles. |
| first_indexed | 2024-12-16T11:33:29Z |
| format | Article |
| id | doaj.art-492900d4e05b45f1880d991918d3a7ca |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-16T11:33:29Z |
| publishDate | 2016-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-492900d4e05b45f1880d991918d3a7ca2022-12-21T22:33:11ZengElsevierJournal of Functional Foods1756-46462016-08-0125110122Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cellsAnat Elmann0Elie Beit-Yannai1Alona Telerman2Rivka Ofir3Sharon Mordechay4Hilla Erlank5Hamutal Borochov-Neori6Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel; Corresponding author. Department of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel. Tel.: +972 3 9683516; fax: +972 3 9683692.Clinical Biochemistry and Pharmacology Department, Ben-Gurion University of the Negev, IsraelDepartment of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, IsraelDead Sea & Arava Science Center, and Department of Immunology and Microbiology, Health Sciences, Ben Gurion University of the Negev, Beer Sheva, IsraelDepartment of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, Israel; Faculty of Agriculture, Food and Environmental Quality Sciences of the Hebrew University of Jerusalem, Rehovot, IsraelDepartment of Food Quality and Safety, The Volcani Center, Agricultural Research Organization, IsraelSouthern Arava Research and Development, Hevel Eilot, IsraelActivated microglial cells release various mediators, which cause neuronal cell death and have been implicated in different neurological disorders. The present study demonstrates that an infusion prepared from the plant Pulicaria incisa (Pi) inhibits microglial activation and down-regulates levels of the inflammatory cytokines interleukin (IL)-1β, IL-6, and of the toxic mediators nitric oxide and glutamate. The infusion was also shown to have antioxidant properties in cell-free assays (e.g., differential pulse voltammetry) and in a cellular assay, in which the infusion attenuated the induced accumulation of intracellular reactive oxygen species (ROS). We found that Pi infusion is rich in polyphenols, especially chlorogenic acids and ferulic acids, which might be responsible for the observed activities. It is proposed that Pi infusion be further evaluated for use as a functional beverage for the prevention and/or treatment of chronic diseases, especially neurodegenerative disorders in which microglial activation and oxidative stress play important roles.http://www.sciencedirect.com/science/article/pii/S1756464616301323Pulicaria incisaHerbal infusionNeuroinflammationMicroglial cellsGlutamatePolyphenols |
| spellingShingle | Anat Elmann Elie Beit-Yannai Alona Telerman Rivka Ofir Sharon Mordechay Hilla Erlank Hamutal Borochov-Neori Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells Journal of Functional Foods Pulicaria incisa Herbal infusion Neuroinflammation Microglial cells Glutamate Polyphenols |
| title | Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells |
| title_full | Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells |
| title_fullStr | Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells |
| title_full_unstemmed | Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells |
| title_short | Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells |
| title_sort | pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells |
| topic | Pulicaria incisa Herbal infusion Neuroinflammation Microglial cells Glutamate Polyphenols |
| url | http://www.sciencedirect.com/science/article/pii/S1756464616301323 |
| work_keys_str_mv | AT anatelmann pulicariaincisainfusionattenuatesinflammatoryresponsesofbrainmicroglialcells AT eliebeityannai pulicariaincisainfusionattenuatesinflammatoryresponsesofbrainmicroglialcells AT alonatelerman pulicariaincisainfusionattenuatesinflammatoryresponsesofbrainmicroglialcells AT rivkaofir pulicariaincisainfusionattenuatesinflammatoryresponsesofbrainmicroglialcells AT sharonmordechay pulicariaincisainfusionattenuatesinflammatoryresponsesofbrainmicroglialcells AT hillaerlank pulicariaincisainfusionattenuatesinflammatoryresponsesofbrainmicroglialcells AT hamutalborochovneori pulicariaincisainfusionattenuatesinflammatoryresponsesofbrainmicroglialcells |