Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders
Odors have proven to be the most resilient trigger for memories of high emotional saliency. Fear associated olfactory memories pose a detrimental threat of potentially transforming into severe mental illness such as fear and anxiety-related disorders. Many studies have deliberated on auditory, visua...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnmol.2019.00221/full |
| _version_ | 1818274864213000192 |
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| author | Marziah Hakim Marziah Hakim Marziah Hakim Andrew R. Battle Andrew R. Battle Andrew R. Battle Andrew R. Battle Arnauld Belmer Arnauld Belmer Selena E. Bartlett Selena E. Bartlett Selena E. Bartlett Luke R. Johnson Luke R. Johnson Luke R. Johnson Luke R. Johnson Fatemeh Chehrehasa Fatemeh Chehrehasa Fatemeh Chehrehasa Fatemeh Chehrehasa |
| author_facet | Marziah Hakim Marziah Hakim Marziah Hakim Andrew R. Battle Andrew R. Battle Andrew R. Battle Andrew R. Battle Arnauld Belmer Arnauld Belmer Selena E. Bartlett Selena E. Bartlett Selena E. Bartlett Luke R. Johnson Luke R. Johnson Luke R. Johnson Luke R. Johnson Fatemeh Chehrehasa Fatemeh Chehrehasa Fatemeh Chehrehasa Fatemeh Chehrehasa |
| author_sort | Marziah Hakim |
| collection | DOAJ |
| description | Odors have proven to be the most resilient trigger for memories of high emotional saliency. Fear associated olfactory memories pose a detrimental threat of potentially transforming into severe mental illness such as fear and anxiety-related disorders. Many studies have deliberated on auditory, visual and general contextual fear memory (CFC) processes; however, fewer studies have investigated mechanisms of olfactory fear memory. Evidence strongly suggests that the neuroanatomical representation of olfactory fear memory differs from that of auditory and visual fear memory. The aim of this review article is to revisit the literature regarding the understanding of the neurobiological process of fear conditioning and to illustrate the circuitry of olfactory fear memory. |
| first_indexed | 2024-12-12T22:20:38Z |
| format | Article |
| id | doaj.art-49296c64bf0f4bb896ab71c8a8c1c6ec |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-12T22:20:38Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-49296c64bf0f4bb896ab71c8a8c1c6ec2022-12-22T00:09:56ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992019-09-011210.3389/fnmol.2019.00221471716Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based DisordersMarziah Hakim0Marziah Hakim1Marziah Hakim2Andrew R. Battle3Andrew R. Battle4Andrew R. Battle5Andrew R. Battle6Arnauld Belmer7Arnauld Belmer8Selena E. Bartlett9Selena E. Bartlett10Selena E. Bartlett11Luke R. Johnson12Luke R. Johnson13Luke R. Johnson14Luke R. Johnson15Fatemeh Chehrehasa16Fatemeh Chehrehasa17Fatemeh Chehrehasa18Fatemeh Chehrehasa19School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, AustraliaInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, AustraliaMater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, AustraliaSchool of Biomedical Science, Queensland University of Technology, Brisbane, QLD, AustraliaInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, AustraliaMater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, AustraliaThe University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, AustraliaInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, AustraliaMater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, AustraliaInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, AustraliaMater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, AustraliaSchool of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Biomedical Science, Queensland University of Technology, Brisbane, QLD, AustraliaMater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, AustraliaDivision of Psychology, School of Medicine, University of Tasmania, Launceston, TAS, AustraliaCenter for the Study of Traumatic Stress, School of Medicine, College of Health and Medicine, Uniformed Services University, Bethesda, MD, United StatesSchool of Biomedical Science, Queensland University of Technology, Brisbane, QLD, AustraliaInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, AustraliaMater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, AustraliaClem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD, AustraliaOdors have proven to be the most resilient trigger for memories of high emotional saliency. Fear associated olfactory memories pose a detrimental threat of potentially transforming into severe mental illness such as fear and anxiety-related disorders. Many studies have deliberated on auditory, visual and general contextual fear memory (CFC) processes; however, fewer studies have investigated mechanisms of olfactory fear memory. Evidence strongly suggests that the neuroanatomical representation of olfactory fear memory differs from that of auditory and visual fear memory. The aim of this review article is to revisit the literature regarding the understanding of the neurobiological process of fear conditioning and to illustrate the circuitry of olfactory fear memory.https://www.frontiersin.org/article/10.3389/fnmol.2019.00221/fullmemoryolfactoryfear conditioningneurogenesisamygdalaneuronal circuits |
| spellingShingle | Marziah Hakim Marziah Hakim Marziah Hakim Andrew R. Battle Andrew R. Battle Andrew R. Battle Andrew R. Battle Arnauld Belmer Arnauld Belmer Selena E. Bartlett Selena E. Bartlett Selena E. Bartlett Luke R. Johnson Luke R. Johnson Luke R. Johnson Luke R. Johnson Fatemeh Chehrehasa Fatemeh Chehrehasa Fatemeh Chehrehasa Fatemeh Chehrehasa Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders Frontiers in Molecular Neuroscience memory olfactory fear conditioning neurogenesis amygdala neuronal circuits |
| title | Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders |
| title_full | Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders |
| title_fullStr | Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders |
| title_full_unstemmed | Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders |
| title_short | Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders |
| title_sort | pavlovian olfactory fear conditioning its neural circuity and importance for understanding clinical fear based disorders |
| topic | memory olfactory fear conditioning neurogenesis amygdala neuronal circuits |
| url | https://www.frontiersin.org/article/10.3389/fnmol.2019.00221/full |
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