Donepezil Treatment of Hypersomnia After COVID-19
The long-term effects of coronavirus disease-2019 (COVID-19) are not yet fully understood and some are due to central nervous system involvement. COVID-19 was reported to cause fatigue in some people after a long-term viral illness, characterized by daytime wakefulness and disturbed sleep cycles. He...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2021-12-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-29726&look4= |
| _version_ | 1828022697101099008 |
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| author | Demet Aygün Üstel Pervin İşeri Meltem Can İke |
| author_facet | Demet Aygün Üstel Pervin İşeri Meltem Can İke |
| author_sort | Demet Aygün Üstel |
| collection | DOAJ |
| description | The long-term effects of coronavirus disease-2019 (COVID-19) are not yet fully understood and some are due to central nervous system involvement. COVID-19 was reported to cause fatigue in some people after a long-term viral illness, characterized by daytime wakefulness and disturbed sleep cycles. Herein, a 90-yearold patient is presented, who developed hypersomnia after COVID-19 and showed signs of cortical atrophy in the left chronic thalamic infarction area and bilateral temporal lobe anteromedial parts in cranial magnetic resonance imaging, as well as increased wakefulness with donepezil treatment. Donepezil is an acetylcholinesterase inhibitor that increases the level of acetylcholinesterase that inhibits gamma-aminobutyric acid release in the forebrain via the serotonin system, which increases dopamine levels in the nucleus accumbens. The serotonin system has been noted for its positive effect on excessive sleepiness and Epworth sleepiness scale score improvement. |
| first_indexed | 2024-04-10T12:14:24Z |
| format | Article |
| id | doaj.art-492c08b14a6f45e489424c01a365b988 |
| institution | Directory Open Access Journal |
| issn | 1309-2545 |
| language | English |
| last_indexed | 2024-04-10T12:14:24Z |
| publishDate | 2021-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-492c08b14a6f45e489424c01a365b9882023-02-15T16:15:50ZengGalenos YayineviTürk Nöroloji Dergisi1309-25452021-12-0127s1434510.4274/tnd.2021.29726Donepezil Treatment of Hypersomnia After COVID-19Demet Aygün Üstel0https://orcid.org/0000-0002-1828-1811Pervin İşeri1https://orcid.org/0000-0002-9582-6627Meltem Can İke2https://orcid.org/0000-0002-3991-9474Istanbul Atlas University Faculty of Medicine, Department of Neurology, Istanbul, TurkeyIstanbul Atlas University Faculty of Medicine, Department of Neurology, Istanbul, TurkeyIstanbul Atlas University Faculty of Medicine, Department of Neurology, Istanbul, TurkeyThe long-term effects of coronavirus disease-2019 (COVID-19) are not yet fully understood and some are due to central nervous system involvement. COVID-19 was reported to cause fatigue in some people after a long-term viral illness, characterized by daytime wakefulness and disturbed sleep cycles. Herein, a 90-yearold patient is presented, who developed hypersomnia after COVID-19 and showed signs of cortical atrophy in the left chronic thalamic infarction area and bilateral temporal lobe anteromedial parts in cranial magnetic resonance imaging, as well as increased wakefulness with donepezil treatment. Donepezil is an acetylcholinesterase inhibitor that increases the level of acetylcholinesterase that inhibits gamma-aminobutyric acid release in the forebrain via the serotonin system, which increases dopamine levels in the nucleus accumbens. The serotonin system has been noted for its positive effect on excessive sleepiness and Epworth sleepiness scale score improvement.https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-29726&look4=covid-19ultradian rhythmhypersomniadonepezil |
| spellingShingle | Demet Aygün Üstel Pervin İşeri Meltem Can İke Donepezil Treatment of Hypersomnia After COVID-19 Türk Nöroloji Dergisi covid-19 ultradian rhythm hypersomnia donepezil |
| title | Donepezil Treatment of Hypersomnia After COVID-19 |
| title_full | Donepezil Treatment of Hypersomnia After COVID-19 |
| title_fullStr | Donepezil Treatment of Hypersomnia After COVID-19 |
| title_full_unstemmed | Donepezil Treatment of Hypersomnia After COVID-19 |
| title_short | Donepezil Treatment of Hypersomnia After COVID-19 |
| title_sort | donepezil treatment of hypersomnia after covid 19 |
| topic | covid-19 ultradian rhythm hypersomnia donepezil |
| url | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-29726&look4= |
| work_keys_str_mv | AT demetaygunustel donepeziltreatmentofhypersomniaaftercovid19 AT perviniseri donepeziltreatmentofhypersomniaaftercovid19 AT meltemcanike donepeziltreatmentofhypersomniaaftercovid19 |