Targeting of temozolomide using magnetic nanobeads: an in vitro study
Temozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2020-09-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100574&tlng=en |
| _version_ | 1818340175194882048 |
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| author | Berna Gürten Elçin Yenigül Ali Demir Sezer Cem Altan Seyda Malta |
| author_facet | Berna Gürten Elçin Yenigül Ali Demir Sezer Cem Altan Seyda Malta |
| author_sort | Berna Gürten |
| collection | DOAJ |
| description | Temozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was encapsulated within the hydrophobic cavities of b-CD modified magnetite nanoparticles, which are embedded in chitosan nanobeads prepared by salt addition. In-vitro studies have shown that the magnetic properties of the novel delivery vehicle are adequate for targeted drug delivery applications under an external magnetic field. Additionally, an increase in the amount of chitosan was shown to exhibit a strong shielding effect over the magnetic properties of the delivery vehicle, which lead to deterioration of the amount of captured drug at the targeted area, suggesting a delicate balance between the amounts of constituents composing the drug delivery vehicle. |
| first_indexed | 2024-12-13T15:38:43Z |
| format | Article |
| id | doaj.art-492d8f65b5ea4ebea8e3de5ebd1307c2 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-13T15:38:43Z |
| publishDate | 2020-09-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-492d8f65b5ea4ebea8e3de5ebd1307c22022-12-21T23:39:53ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902020-09-015610.1590/s2175-97902019000418579Targeting of temozolomide using magnetic nanobeads: an in vitro studyBerna GürtenElçin YenigülAli Demir Sezerhttps://orcid.org/0000-0002-2678-8903Cem AltanSeyda MaltaTemozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was encapsulated within the hydrophobic cavities of b-CD modified magnetite nanoparticles, which are embedded in chitosan nanobeads prepared by salt addition. In-vitro studies have shown that the magnetic properties of the novel delivery vehicle are adequate for targeted drug delivery applications under an external magnetic field. Additionally, an increase in the amount of chitosan was shown to exhibit a strong shielding effect over the magnetic properties of the delivery vehicle, which lead to deterioration of the amount of captured drug at the targeted area, suggesting a delicate balance between the amounts of constituents composing the drug delivery vehicle.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100574&tlng=enTemozolomideMagnetiteCyclodextrinChitosanTargetingAnticancer |
| spellingShingle | Berna Gürten Elçin Yenigül Ali Demir Sezer Cem Altan Seyda Malta Targeting of temozolomide using magnetic nanobeads: an in vitro study Brazilian Journal of Pharmaceutical Sciences Temozolomide Magnetite Cyclodextrin Chitosan Targeting Anticancer |
| title | Targeting of temozolomide using magnetic nanobeads: an in vitro study |
| title_full | Targeting of temozolomide using magnetic nanobeads: an in vitro study |
| title_fullStr | Targeting of temozolomide using magnetic nanobeads: an in vitro study |
| title_full_unstemmed | Targeting of temozolomide using magnetic nanobeads: an in vitro study |
| title_short | Targeting of temozolomide using magnetic nanobeads: an in vitro study |
| title_sort | targeting of temozolomide using magnetic nanobeads an in vitro study |
| topic | Temozolomide Magnetite Cyclodextrin Chitosan Targeting Anticancer |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100574&tlng=en |
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