Spontaneous Control of SIV Replication Does Not Prevent T Cell Dysregulation and Bacterial Dissemination in Animals Co-Infected with M. tuberculosis

Spontaneous Control of SIV Replication Does Not Prevent T Cell Dysregulation and Bacterial Dissemination in Animals Co-Infected with M. tuberculosis

ABSTRACT Individuals co-infected with HIV and Mycobacterium tuberculosis (Mtb) are more likely to develop severe tuberculosis (TB) disease than HIV-naive individuals. To understand how a chronic pre-existing Simian immunodeficiency virus (SIV) infection impairs the early immune response to Mtb, we u...

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Bibliographic Details
Main Authors: Ryan V. Moriarty, Mark A. Rodgers, Amy L. Ellis, Alexis J. Balgeman, Erica C. Larson, Forrest Hopkins, Michael R. Chase, Pauline Maiello, Sarah M. Fortune, Charles A. Scanga, Shelby L. O’Connor
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
MCM
Mtb
SIV
coinfection
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01724-21

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