Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle
Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunction...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2018.1428241 |
| _version_ | 1819230102893887488 |
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| author | Zuwu Wei Ming Wu Zuanfang Li Zhan Lin Jinhua Zeng Haiyan Sun Xiaolong Liu Jingfeng Liu Buhong Li Yongyi Zeng |
| author_facet | Zuwu Wei Ming Wu Zuanfang Li Zhan Lin Jinhua Zeng Haiyan Sun Xiaolong Liu Jingfeng Liu Buhong Li Yongyi Zeng |
| author_sort | Zuwu Wei |
| collection | DOAJ |
| description | Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO2-ZrO2/DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO2-ZrO2/DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging. |
| first_indexed | 2024-12-23T11:23:44Z |
| format | Article |
| id | doaj.art-492f658e5dda4c8da942173db611b815 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-23T11:23:44Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-492f658e5dda4c8da942173db611b8152022-12-21T17:49:00ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642018-01-0125135336310.1080/10717544.2018.14282411428241Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicleZuwu Wei0Ming Wu1Zuanfang Li2Zhan Lin3Jinhua Zeng4Haiyan Sun5Xiaolong Liu6Jingfeng Liu7Buhong Li8Yongyi Zeng9the First Affiliated Hospital of Fujian Medical UniversityMengchao Hepatobiliary Hospital of Fujian Medical UniversityFujian University of Traditional Chinese MedicineMengchao Hepatobiliary Hospital of Fujian Medical Universitythe First Affiliated Hospital of Fujian Medical UniversityBeijing Anzhen Hospital Capital Medical UniversityMengchao Hepatobiliary Hospital of Fujian Medical Universitythe First Affiliated Hospital of Fujian Medical UniversityFujian Normal Universitythe First Affiliated Hospital of Fujian Medical UniversityDeveloping multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO2-ZrO2/DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO2-ZrO2/DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.http://dx.doi.org/10.1080/10717544.2018.1428241drug deliverynanoplatformdual-modal imagingtheranosticmultifunctional |
| spellingShingle | Zuwu Wei Ming Wu Zuanfang Li Zhan Lin Jinhua Zeng Haiyan Sun Xiaolong Liu Jingfeng Liu Buhong Li Yongyi Zeng Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle Drug Delivery drug delivery nanoplatform dual-modal imaging theranostic multifunctional |
| title | Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle |
| title_full | Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle |
| title_fullStr | Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle |
| title_full_unstemmed | Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle |
| title_short | Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle |
| title_sort | gadolinium doped hollow ceo2 zro2 nanoplatform as multifunctional mri ct dual modal imaging agent and drug delivery vehicle |
| topic | drug delivery nanoplatform dual-modal imaging theranostic multifunctional |
| url | http://dx.doi.org/10.1080/10717544.2018.1428241 |
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