Lamin B1 as a key modulator of the developing and aging brain
Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear function and organization. It has been demonstrated that lamin B1 is essential for organogenesis and particularly brain development. The important role of lamin B1 in physiological brain development and aging...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1263310/full |
| _version_ | 1797730311950303232 |
|---|---|
| author | Foteini-Dionysia Koufi Irene Neri Giulia Ramazzotti Isabella Rusciano Sara Mongiorgi Maria Vittoria Marvi Antonietta Fazio Minkyung Shin Yoichi Kosodo Ilaria Cani Elisa Giorgio Elisa Giorgio Pietro Cortelli Pietro Cortelli Lucia Manzoli Stefano Ratti |
| author_facet | Foteini-Dionysia Koufi Irene Neri Giulia Ramazzotti Isabella Rusciano Sara Mongiorgi Maria Vittoria Marvi Antonietta Fazio Minkyung Shin Yoichi Kosodo Ilaria Cani Elisa Giorgio Elisa Giorgio Pietro Cortelli Pietro Cortelli Lucia Manzoli Stefano Ratti |
| author_sort | Foteini-Dionysia Koufi |
| collection | DOAJ |
| description | Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear function and organization. It has been demonstrated that lamin B1 is essential for organogenesis and particularly brain development. The important role of lamin B1 in physiological brain development and aging has only recently been at the epicenter of attention and is yet to be fully elucidated. Regarding the development of brain, glial cells that have long been considered as supporting cells to neurons have overturned this representation and current findings have displayed their active roles in neurogenesis and cerebral development. Although lamin B1 has increased levels during the differentiation of the brain cells, during aging these levels drop leading to senescent phenotypes and inciting neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. On the other hand, overexpression of lamin B1 leads to the adult-onset neurodegenerative disease known as Autosomal Dominant Leukodystrophy. This review aims at highlighting the importance of balancing lamin B1 levels in glial cells and neurons from brain development to aging. |
| first_indexed | 2024-03-12T11:43:23Z |
| format | Article |
| id | doaj.art-4930a394323e4810b2513ff640342165 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-03-12T11:43:23Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-4930a394323e4810b2513ff6403421652023-08-31T12:48:26ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-08-011710.3389/fncel.2023.12633101263310Lamin B1 as a key modulator of the developing and aging brainFoteini-Dionysia Koufi0Irene Neri1Giulia Ramazzotti2Isabella Rusciano3Sara Mongiorgi4Maria Vittoria Marvi5Antonietta Fazio6Minkyung Shin7Yoichi Kosodo8Ilaria Cani9Elisa Giorgio10Elisa Giorgio11Pietro Cortelli12Pietro Cortelli13Lucia Manzoli14Stefano Ratti15Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, ItalyKorea Brain Research Institute (KBRI), Daegu, Republic of KoreaKorea Brain Research Institute (KBRI), Daegu, Republic of KoreaDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyMedical Genetics Unit, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, ItalyIRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, ItalyLamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear function and organization. It has been demonstrated that lamin B1 is essential for organogenesis and particularly brain development. The important role of lamin B1 in physiological brain development and aging has only recently been at the epicenter of attention and is yet to be fully elucidated. Regarding the development of brain, glial cells that have long been considered as supporting cells to neurons have overturned this representation and current findings have displayed their active roles in neurogenesis and cerebral development. Although lamin B1 has increased levels during the differentiation of the brain cells, during aging these levels drop leading to senescent phenotypes and inciting neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. On the other hand, overexpression of lamin B1 leads to the adult-onset neurodegenerative disease known as Autosomal Dominant Leukodystrophy. This review aims at highlighting the importance of balancing lamin B1 levels in glial cells and neurons from brain development to aging.https://www.frontiersin.org/articles/10.3389/fncel.2023.1263310/fulllamin B1nuclear laminagliaastrocytesneurogenesisneurons |
| spellingShingle | Foteini-Dionysia Koufi Irene Neri Giulia Ramazzotti Isabella Rusciano Sara Mongiorgi Maria Vittoria Marvi Antonietta Fazio Minkyung Shin Yoichi Kosodo Ilaria Cani Elisa Giorgio Elisa Giorgio Pietro Cortelli Pietro Cortelli Lucia Manzoli Stefano Ratti Lamin B1 as a key modulator of the developing and aging brain Frontiers in Cellular Neuroscience lamin B1 nuclear lamina glia astrocytes neurogenesis neurons |
| title | Lamin B1 as a key modulator of the developing and aging brain |
| title_full | Lamin B1 as a key modulator of the developing and aging brain |
| title_fullStr | Lamin B1 as a key modulator of the developing and aging brain |
| title_full_unstemmed | Lamin B1 as a key modulator of the developing and aging brain |
| title_short | Lamin B1 as a key modulator of the developing and aging brain |
| title_sort | lamin b1 as a key modulator of the developing and aging brain |
| topic | lamin B1 nuclear lamina glia astrocytes neurogenesis neurons |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1263310/full |
| work_keys_str_mv | AT foteinidionysiakoufi laminb1asakeymodulatorofthedevelopingandagingbrain AT ireneneri laminb1asakeymodulatorofthedevelopingandagingbrain AT giuliaramazzotti laminb1asakeymodulatorofthedevelopingandagingbrain AT isabellarusciano laminb1asakeymodulatorofthedevelopingandagingbrain AT saramongiorgi laminb1asakeymodulatorofthedevelopingandagingbrain AT mariavittoriamarvi laminb1asakeymodulatorofthedevelopingandagingbrain AT antoniettafazio laminb1asakeymodulatorofthedevelopingandagingbrain AT minkyungshin laminb1asakeymodulatorofthedevelopingandagingbrain AT yoichikosodo laminb1asakeymodulatorofthedevelopingandagingbrain AT ilariacani laminb1asakeymodulatorofthedevelopingandagingbrain AT elisagiorgio laminb1asakeymodulatorofthedevelopingandagingbrain AT elisagiorgio laminb1asakeymodulatorofthedevelopingandagingbrain AT pietrocortelli laminb1asakeymodulatorofthedevelopingandagingbrain AT pietrocortelli laminb1asakeymodulatorofthedevelopingandagingbrain AT luciamanzoli laminb1asakeymodulatorofthedevelopingandagingbrain AT stefanoratti laminb1asakeymodulatorofthedevelopingandagingbrain |