The relationship between retinal layers and brain areas in asymptomatic first-degree relatives of sporadic forms of Alzheimer’s disease: an exploratory analysis

The relationship between retinal layers and brain areas in asymptomatic first-degree relatives of sporadic forms of Alzheimer’s disease: an exploratory analysis

Abstract Background Two main genetic risks for sporadic Alzheimer’s disease (AD) are a family history and ɛ4 allele of apolipoprotein E. The brain and retina are part of the central nervous system and share pathophysiological mechanisms in AD. Methods We performed a cross-sectional study with 30 par...

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Bibliographic Details
Main Authors: Inés López-Cuenca, Alberto Marcos-Dolado, Miguel Yus-Fuertes, Elena Salobrar-García, Lorena Elvira-Hurtado, José A. Fernández-Albarral, Juan J. Salazar, Ana I. Ramírez, Lidia Sánchez-Puebla, Manuel Enrique Fuentes-Ferrer, Ana Barabash, Federico Ramírez-Toraño, Lidia Gil-Martínez, Juan Arrazola-García, Pedro Gil, Rosa de Hoz, José M. Ramírez
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Family history
ApoE ɛ4
Retina
OCT
MRI
Online Access:https://doi.org/10.1186/s13195-022-01008-5

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