Fibroblast-derived CXCL12 increases vascular permeability in a 3-D microfluidic model independent of extracellular matrix contractility

Fibroblast-derived CXCL12 increases vascular permeability in a 3-D microfluidic model independent of extracellular matrix contractility

Cancer-associated fibroblasts (CAFs) play an active role in remodeling the local tumor stroma to support tumor initiation, growth, invasion, metastasis, and therapeutic resistance. The CAF-secreted chemokine, CXCL12, has been directly implicated in the tumorigenic progression of carcinomas, includin...

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Bibliographic Details
Main Authors: Jacob C. Holter, Chia-Wen Chang, Alex Avendano, Ayush A. Garg, Ajeet K. Verma, Manish Charan, Dinesh K. Ahirwar, Ramesh K. Ganju, Jonathan W. Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
microfluidics
tumor microenvironment
cancer-associated fibroblast
paracrine signaling
collagen hydrogel
microtissue analogue
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.888431/full

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