Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study
BackgroundThe aim of our study was to evaluate the degree of genetic homozygosity in cardiac surgical patients with postoperative acute kidney injury (AKI), compared to the subgroup without postoperative AKI, as well as to evaluate antropomorpho-genetic variability in cardiac surgical patients with...
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Frontiers Media S.A.
2022-09-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.943254/full |
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author | Radmila Karan Radmila Karan Natasa Kovačević-Kostić Natasa Kovačević-Kostić Bratislav Kirćanski Bratislav Kirćanski Jelena Čumić Jelena Čumić Duško Terzić Duško Terzić Vladimir Milićević Vojislav Velinović Miloš Velinović Miloš Velinović Biljana Obrenović-Kirćanski Biljana Obrenović-Kirćanski |
author_facet | Radmila Karan Radmila Karan Natasa Kovačević-Kostić Natasa Kovačević-Kostić Bratislav Kirćanski Bratislav Kirćanski Jelena Čumić Jelena Čumić Duško Terzić Duško Terzić Vladimir Milićević Vojislav Velinović Miloš Velinović Miloš Velinović Biljana Obrenović-Kirćanski Biljana Obrenović-Kirćanski |
author_sort | Radmila Karan |
collection | DOAJ |
description | BackgroundThe aim of our study was to evaluate the degree of genetic homozygosity in cardiac surgical patients with postoperative acute kidney injury (AKI), compared to the subgroup without postoperative AKI, as well as to evaluate antropomorpho-genetic variability in cardiac surgical patients with regard to the presence and severity degree of AKI.Materials and methodsThe prospective cohort study included an analysis of 138 eligible coronary artery disease (CAD) surgical patients that were screened consecutively. The tested group was divided into three subgroups according to RIFLE criteria: Subgroup NoAKI (N = 91), risk (N = 31), and injury (N = 16). All individuals were evaluated for the presence of 19 observable recessive human traits (ORHT) as a marker of chromosomal homozygosity and variability.ResultsComparing subgroups NoAKI and risk, four ORHTs were significantly more frequent in the risk subgroup. Comparing subgroups NoAKI and injury, nine ORHTs were significantly more frequent in the injury subgroup; while comparing the injury subgroup and risk, five ORHTs were significantly more frequent in injury than in the risk subgroup. Results also showed a significant increase in the mean value of ORHTs for the injury subgroup compared to NoAKI subgroup (p = 0.039). Variability decreased proportionally to the increase in the severity of AKI (VNoAKI = 32.81%, VRisk = 30.92%, and VInjury = 28.62%).ConclusionOur findings pointed to the higher degree of recessive homozygosity and decreased variability in AKI patients vs. NoAKI individuals, thus presumably facilitating the development and severity degree expression of AKI in patients after cardiac surgery. |
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language | English |
last_indexed | 2024-04-11T20:27:00Z |
publishDate | 2022-09-01 |
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spelling | doaj.art-49342fbc3ccf43c2a1ddd922e5ac9c222022-12-22T04:04:38ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-09-01910.3389/fmed.2022.943254943254Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot studyRadmila Karan0Radmila Karan1Natasa Kovačević-Kostić2Natasa Kovačević-Kostić3Bratislav Kirćanski4Bratislav Kirćanski5Jelena Čumić6Jelena Čumić7Duško Terzić8Duško Terzić9Vladimir Milićević10Vojislav Velinović11Miloš Velinović12Miloš Velinović13Biljana Obrenović-Kirćanski14Biljana Obrenović-Kirćanski15Faculty of Medicine, University of Belgrade, Belgrade, SerbiaDepartment of Anesthesiology and Intensive Care at Clinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaDepartment of Anesthesiology and Intensive Care at Clinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaPacemaker Center, Clinical Center of Serbia, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaDepartment of Anesthesiology and Intensive Care at Clinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaDepartment for Transplantation and LVAD at Clinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade, SerbiaClinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade, SerbiaClinic for Cardiology, Clinical Center of Serbia, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaClinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaClinic for Cardiology, Clinical Center of Serbia, Belgrade, SerbiaBackgroundThe aim of our study was to evaluate the degree of genetic homozygosity in cardiac surgical patients with postoperative acute kidney injury (AKI), compared to the subgroup without postoperative AKI, as well as to evaluate antropomorpho-genetic variability in cardiac surgical patients with regard to the presence and severity degree of AKI.Materials and methodsThe prospective cohort study included an analysis of 138 eligible coronary artery disease (CAD) surgical patients that were screened consecutively. The tested group was divided into three subgroups according to RIFLE criteria: Subgroup NoAKI (N = 91), risk (N = 31), and injury (N = 16). All individuals were evaluated for the presence of 19 observable recessive human traits (ORHT) as a marker of chromosomal homozygosity and variability.ResultsComparing subgroups NoAKI and risk, four ORHTs were significantly more frequent in the risk subgroup. Comparing subgroups NoAKI and injury, nine ORHTs were significantly more frequent in the injury subgroup; while comparing the injury subgroup and risk, five ORHTs were significantly more frequent in injury than in the risk subgroup. Results also showed a significant increase in the mean value of ORHTs for the injury subgroup compared to NoAKI subgroup (p = 0.039). Variability decreased proportionally to the increase in the severity of AKI (VNoAKI = 32.81%, VRisk = 30.92%, and VInjury = 28.62%).ConclusionOur findings pointed to the higher degree of recessive homozygosity and decreased variability in AKI patients vs. NoAKI individuals, thus presumably facilitating the development and severity degree expression of AKI in patients after cardiac surgery.https://www.frontiersin.org/articles/10.3389/fmed.2022.943254/fullcoronary artery diseaseobservable recessive human traitsacute kidney injuryvariabilitycardiac surgery |
spellingShingle | Radmila Karan Radmila Karan Natasa Kovačević-Kostić Natasa Kovačević-Kostić Bratislav Kirćanski Bratislav Kirćanski Jelena Čumić Jelena Čumić Duško Terzić Duško Terzić Vladimir Milićević Vojislav Velinović Miloš Velinović Miloš Velinović Biljana Obrenović-Kirćanski Biljana Obrenović-Kirćanski Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study Frontiers in Medicine coronary artery disease observable recessive human traits acute kidney injury variability cardiac surgery |
title | Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study |
title_full | Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study |
title_fullStr | Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study |
title_full_unstemmed | Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study |
title_short | Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study |
title_sort | morphogenetic dispositions for variability in acute kidney injury after cardiac surgery pilot study |
topic | coronary artery disease observable recessive human traits acute kidney injury variability cardiac surgery |
url | https://www.frontiersin.org/articles/10.3389/fmed.2022.943254/full |
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