Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human Myocardium
Background Because body mass index (BMI) is generally used clinically to define obesity and to estimate body adiposity, BMI likely is positively correlated with epicardial adipose tissue (EAT) level. Based on echocardiography, previous outcomes on this matter have varied from almost absent to rather...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-07-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.025405 |
| _version_ | 1811167037091741696 |
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| author | Kyra K. Peczkowski Mohammed A. Mashali Nancy S. Saad Austin Hare Courtney M. Campbell Bryan A. Whitson Nahush A. Mokadam Paul M. L. Janssen |
| author_facet | Kyra K. Peczkowski Mohammed A. Mashali Nancy S. Saad Austin Hare Courtney M. Campbell Bryan A. Whitson Nahush A. Mokadam Paul M. L. Janssen |
| author_sort | Kyra K. Peczkowski |
| collection | DOAJ |
| description | Background Because body mass index (BMI) is generally used clinically to define obesity and to estimate body adiposity, BMI likely is positively correlated with epicardial adipose tissue (EAT) level. Based on echocardiography, previous outcomes on this matter have varied from almost absent to rather strong correlations between BMI and EAT. The purpose of our study was to unambiguously examine EAT content and determine if correlations exist between EAT content and BMI, cause of heart failure, or contractile force. Methods and Results We qualitatively scored 150 human hearts ex vivo on EAT distribution. From each heart, multiple photographs of the heart were taken, and both atrial and ventricular adipose tissue levels were semiquantitatively scored. Main findings include a generally higher EAT content on nonfailing hearts compared with end‐stage failing hearts (atrial adipose tissue level 5.70±0.13 vs. 5.00±0.12, P<0.001; ventricular adipose tissue level 5.14±0.16 vs. 4.57±0.12, P=0.0048). The results also suggest that EAT quantity is not strongly correlated with BMI in nonfailing (atrial adipose tissue level r=0.069, ventricular adipose tissue level r=0.14) or failing (atrial adipose tissue level r=−0.022, ventricular adipose tissue level r=0.051) hearts. Atrial EAT is closely correlated with ventricular EAT in both nonfailing (r=0.92, P<0.001) and failing (r=0.87, P<0.001) hearts. Conclusions EAT volume appears to be inversely proportional to severity of or length of time with heart failure based on our findings. Based on a lack of correlation with BMI, it is incorrect to assume high EAT volume given high body fat percentage. |
| first_indexed | 2024-04-10T16:02:24Z |
| format | Article |
| id | doaj.art-4937f14f56824b55bf907b9a557c082a |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-10T16:02:24Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-4937f14f56824b55bf907b9a557c082a2023-02-10T09:15:42ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-07-01111310.1161/JAHA.121.025405Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human MyocardiumKyra K. Peczkowski0Mohammed A. Mashali1Nancy S. Saad2Austin Hare3Courtney M. Campbell4Bryan A. Whitson5Nahush A. Mokadam6Paul M. L. Janssen7Department of Physiology and Cell Biology College of Medicine The Ohio State University Columbus OHDepartment of Physiology and Cell Biology College of Medicine The Ohio State University Columbus OHDepartment of Physiology and Cell Biology College of Medicine The Ohio State University Columbus OHDepartment of Physiology and Cell Biology College of Medicine The Ohio State University Columbus OHDepartment of Physiology and Cell Biology College of Medicine The Ohio State University Columbus OHDivision of Cardiac Surgery College of Medicine The Ohio State University Columbus OHDivision of Cardiac Surgery College of Medicine The Ohio State University Columbus OHDepartment of Physiology and Cell Biology College of Medicine The Ohio State University Columbus OHBackground Because body mass index (BMI) is generally used clinically to define obesity and to estimate body adiposity, BMI likely is positively correlated with epicardial adipose tissue (EAT) level. Based on echocardiography, previous outcomes on this matter have varied from almost absent to rather strong correlations between BMI and EAT. The purpose of our study was to unambiguously examine EAT content and determine if correlations exist between EAT content and BMI, cause of heart failure, or contractile force. Methods and Results We qualitatively scored 150 human hearts ex vivo on EAT distribution. From each heart, multiple photographs of the heart were taken, and both atrial and ventricular adipose tissue levels were semiquantitatively scored. Main findings include a generally higher EAT content on nonfailing hearts compared with end‐stage failing hearts (atrial adipose tissue level 5.70±0.13 vs. 5.00±0.12, P<0.001; ventricular adipose tissue level 5.14±0.16 vs. 4.57±0.12, P=0.0048). The results also suggest that EAT quantity is not strongly correlated with BMI in nonfailing (atrial adipose tissue level r=0.069, ventricular adipose tissue level r=0.14) or failing (atrial adipose tissue level r=−0.022, ventricular adipose tissue level r=0.051) hearts. Atrial EAT is closely correlated with ventricular EAT in both nonfailing (r=0.92, P<0.001) and failing (r=0.87, P<0.001) hearts. Conclusions EAT volume appears to be inversely proportional to severity of or length of time with heart failure based on our findings. Based on a lack of correlation with BMI, it is incorrect to assume high EAT volume given high body fat percentage.https://www.ahajournals.org/doi/10.1161/JAHA.121.025405BMIcardiomyopathyheart failureobesitypathogenesis |
| spellingShingle | Kyra K. Peczkowski Mohammed A. Mashali Nancy S. Saad Austin Hare Courtney M. Campbell Bryan A. Whitson Nahush A. Mokadam Paul M. L. Janssen Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human Myocardium Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease BMI cardiomyopathy heart failure obesity pathogenesis |
| title | Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human Myocardium |
| title_full | Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human Myocardium |
| title_fullStr | Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human Myocardium |
| title_full_unstemmed | Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human Myocardium |
| title_short | Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human Myocardium |
| title_sort | quantification of cardiac adipose tissue in failing and nonfailing human myocardium |
| topic | BMI cardiomyopathy heart failure obesity pathogenesis |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.025405 |
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