The role of adipokines in gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is a complication of pregnancy that is characterized by impaired glucose tolerance with onset or first recognition during pregnancy. The reported prevalence of GDM varies between 0.6% and 20% of pregnancies depending on screening method, gestational age and the po...

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Main Authors: Marwa R. Al-Badri, Mira S. Zantout, Sami T. Azar
Format: Article
Language:English
Published: SAGE Publishing 2015-06-01
Series:Therapeutic Advances in Endocrinology and Metabolism
Online Access:https://doi.org/10.1177/2042018815577039
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author Marwa R. Al-Badri
Mira S. Zantout
Sami T. Azar
author_facet Marwa R. Al-Badri
Mira S. Zantout
Sami T. Azar
author_sort Marwa R. Al-Badri
collection DOAJ
description Gestational diabetes mellitus (GDM) is a complication of pregnancy that is characterized by impaired glucose tolerance with onset or first recognition during pregnancy. The reported prevalence of GDM varies between 0.6% and 20% of pregnancies depending on screening method, gestational age and the population studied. GDM is characterized by pancreatic β-cell function that is insufficient to meet the body’s insulin needs. Available evidence suggests that β-cell defects in GDM result from the same spectrum of causes that underline hyperglycemia in general, including autoimmune disease, monogenic causes and insulin resistance. Adipokines are proteins secreted from the adipocytes and are believed to have a metabolic influence. Our review suggests that, in GDM, various adipokines, mainly leptin and adiponectin, are dysregulated. These two adipokines might have both prognostic and pathophysiological significance in this disease.
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spelling doaj.art-4937f2bb2e0b4ed7b8784979c15bb07a2022-12-21T19:26:47ZengSAGE PublishingTherapeutic Advances in Endocrinology and Metabolism2042-01882042-01962015-06-01610.1177/2042018815577039The role of adipokines in gestational diabetes mellitusMarwa R. Al-BadriMira S. ZantoutSami T. AzarGestational diabetes mellitus (GDM) is a complication of pregnancy that is characterized by impaired glucose tolerance with onset or first recognition during pregnancy. The reported prevalence of GDM varies between 0.6% and 20% of pregnancies depending on screening method, gestational age and the population studied. GDM is characterized by pancreatic β-cell function that is insufficient to meet the body’s insulin needs. Available evidence suggests that β-cell defects in GDM result from the same spectrum of causes that underline hyperglycemia in general, including autoimmune disease, monogenic causes and insulin resistance. Adipokines are proteins secreted from the adipocytes and are believed to have a metabolic influence. Our review suggests that, in GDM, various adipokines, mainly leptin and adiponectin, are dysregulated. These two adipokines might have both prognostic and pathophysiological significance in this disease.https://doi.org/10.1177/2042018815577039
spellingShingle Marwa R. Al-Badri
Mira S. Zantout
Sami T. Azar
The role of adipokines in gestational diabetes mellitus
Therapeutic Advances in Endocrinology and Metabolism
title The role of adipokines in gestational diabetes mellitus
title_full The role of adipokines in gestational diabetes mellitus
title_fullStr The role of adipokines in gestational diabetes mellitus
title_full_unstemmed The role of adipokines in gestational diabetes mellitus
title_short The role of adipokines in gestational diabetes mellitus
title_sort role of adipokines in gestational diabetes mellitus
url https://doi.org/10.1177/2042018815577039
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