An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management
Presently, notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/12/1215 |
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| author | Elena-Emilia Tudoroiu Cristina-Elena Dinu-Pîrvu Mădălina Georgiana Albu Kaya Lăcrămioara Popa Valentina Anuța Răzvan Mihai Prisada Mihaela Violeta Ghica |
| author_facet | Elena-Emilia Tudoroiu Cristina-Elena Dinu-Pîrvu Mădălina Georgiana Albu Kaya Lăcrămioara Popa Valentina Anuța Răzvan Mihai Prisada Mihaela Violeta Ghica |
| author_sort | Elena-Emilia Tudoroiu |
| collection | DOAJ |
| description | Presently, notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based on cellulose derivatives. Cellulose derivatives are semi-synthetic biopolymers, which exhibit high solubility in water and represent an advantageous alternative to water-insoluble cellulose. These biopolymers possess excellent properties, such as biocompatibility, biodegradability, sustainability, non-toxicity, non-immunogenicity, thermo-gelling behavior, mechanical strength, abundance, low costs, antibacterial effect, and high hydrophilicity. They have an efficient ability to absorb and retain a large quantity of wound exudates in the interstitial sites of their networks and can maintain optimal local moisture. Cellulose derivatives also represent a proper scaffold to incorporate various bioactive agents with beneficial therapeutic effects on skin tissue restoration. Due to these suitable and versatile characteristics, cellulose derivatives are attractive and captivating materials for wound-healing applications. This review presents an extensive overview of recent research regarding promising cellulose derivatives-based materials for the development of multiple biomedical and pharmaceutical applications, such as wound dressings, drug delivery devices, and tissue engineering. |
| first_indexed | 2024-03-10T03:21:19Z |
| format | Article |
| id | doaj.art-49382d5dc98848f8a30e97f3d0660778 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:21:19Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-49382d5dc98848f8a30e97f3d06607782023-11-23T10:02:33ZengMDPI AGPharmaceuticals1424-82472021-11-011412121510.3390/ph14121215An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing ManagementElena-Emilia Tudoroiu0Cristina-Elena Dinu-Pîrvu1Mădălina Georgiana Albu Kaya2Lăcrămioara Popa3Valentina Anuța4Răzvan Mihai Prisada5Mihaela Violeta Ghica6Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Collagen, Division Leather and Footwear Research Institute, National Research and Development Institute for Textile and Leather, 93 Ion Minulescu Str., 031215 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Str., 020956 Bucharest, RomaniaPresently, notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based on cellulose derivatives. Cellulose derivatives are semi-synthetic biopolymers, which exhibit high solubility in water and represent an advantageous alternative to water-insoluble cellulose. These biopolymers possess excellent properties, such as biocompatibility, biodegradability, sustainability, non-toxicity, non-immunogenicity, thermo-gelling behavior, mechanical strength, abundance, low costs, antibacterial effect, and high hydrophilicity. They have an efficient ability to absorb and retain a large quantity of wound exudates in the interstitial sites of their networks and can maintain optimal local moisture. Cellulose derivatives also represent a proper scaffold to incorporate various bioactive agents with beneficial therapeutic effects on skin tissue restoration. Due to these suitable and versatile characteristics, cellulose derivatives are attractive and captivating materials for wound-healing applications. This review presents an extensive overview of recent research regarding promising cellulose derivatives-based materials for the development of multiple biomedical and pharmaceutical applications, such as wound dressings, drug delivery devices, and tissue engineering.https://www.mdpi.com/1424-8247/14/12/1215cellulose derivativeswound dressingswound managementbioactive agents delivery systems |
| spellingShingle | Elena-Emilia Tudoroiu Cristina-Elena Dinu-Pîrvu Mădălina Georgiana Albu Kaya Lăcrămioara Popa Valentina Anuța Răzvan Mihai Prisada Mihaela Violeta Ghica An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management Pharmaceuticals cellulose derivatives wound dressings wound management bioactive agents delivery systems |
| title | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
| title_full | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
| title_fullStr | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
| title_full_unstemmed | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
| title_short | An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management |
| title_sort | overview of cellulose derivatives based dressings for wound healing management |
| topic | cellulose derivatives wound dressings wound management bioactive agents delivery systems |
| url | https://www.mdpi.com/1424-8247/14/12/1215 |
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