Seasonal Bordetella pertussis pattern in the period from 2008 to 2018 in Germany
Abstract Background After the introduction of a vaccine against B. pertussis the seasonal pattern with the highest number of infections in the spring to summer months changed. Recent studies from around the world suggest that B. pertussis infections again follow a seasonal pattern with increased inc...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05199-w |
| _version_ | 1818275144700788736 |
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| author | Daniel Allermann Hitz Friedemann Tewald Maren Eggers |
| author_facet | Daniel Allermann Hitz Friedemann Tewald Maren Eggers |
| author_sort | Daniel Allermann Hitz |
| collection | DOAJ |
| description | Abstract Background After the introduction of a vaccine against B. pertussis the seasonal pattern with the highest number of infections in the spring to summer months changed. Recent studies from around the world suggest that B. pertussis infections again follow a seasonal pattern with increased incidence in summer.The aim of this study was to investigate whether respiratory infections caused by B. pertussis in the period from January 2008 to December 2018 also seasonally spread in Germany and if so, when the B. pertussis activity peaked. Methods We tested 19,031 samples, mainly from Southern Germany, collected in the period from January 2008 to December 2018 using a Multiplex PCR assay. We assessed the number and proportion of samples positive for B. pertussis, stratified by patient’s age and month. The seasonal distribution was investigated by plotting the average proportion of positive samples for each month. Results We observed a B. pertussis seasonality with the highest number of positive samples in the months from June until September. In contrast, testing of samples for B. pertussis was requested most frequently in the period from October until March. The proportion of positive samples increased earlier in adolescents (age 10 to 19) than in other age groups. Conclusions We found a seasonality of B. pertussis infections in Germany, which differs from the time when most samples are sent in for testing of B. pertussis. Our study suggests that clinicians should be more aware of B. pertussis infections in the months from June until September to prevent further transmission to vulnerable family members. |
| first_indexed | 2024-12-12T22:25:05Z |
| format | Article |
| id | doaj.art-4939a7623c044fc9a1cac49a49982284 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T22:25:05Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-4939a7623c044fc9a1cac49a499822842022-12-22T00:09:47ZengBMCBMC Infectious Diseases1471-23342020-07-012011610.1186/s12879-020-05199-wSeasonal Bordetella pertussis pattern in the period from 2008 to 2018 in GermanyDaniel Allermann Hitz0Friedemann Tewald1Maren Eggers2Laboratory Prof. Gisela Enders and colleagues, MVZLaboratory Prof. Gisela Enders and colleagues, MVZLaboratory Prof. Gisela Enders and colleagues, MVZAbstract Background After the introduction of a vaccine against B. pertussis the seasonal pattern with the highest number of infections in the spring to summer months changed. Recent studies from around the world suggest that B. pertussis infections again follow a seasonal pattern with increased incidence in summer.The aim of this study was to investigate whether respiratory infections caused by B. pertussis in the period from January 2008 to December 2018 also seasonally spread in Germany and if so, when the B. pertussis activity peaked. Methods We tested 19,031 samples, mainly from Southern Germany, collected in the period from January 2008 to December 2018 using a Multiplex PCR assay. We assessed the number and proportion of samples positive for B. pertussis, stratified by patient’s age and month. The seasonal distribution was investigated by plotting the average proportion of positive samples for each month. Results We observed a B. pertussis seasonality with the highest number of positive samples in the months from June until September. In contrast, testing of samples for B. pertussis was requested most frequently in the period from October until March. The proportion of positive samples increased earlier in adolescents (age 10 to 19) than in other age groups. Conclusions We found a seasonality of B. pertussis infections in Germany, which differs from the time when most samples are sent in for testing of B. pertussis. Our study suggests that clinicians should be more aware of B. pertussis infections in the months from June until September to prevent further transmission to vulnerable family members.http://link.springer.com/article/10.1186/s12879-020-05199-wPertussisWhooping coughSeasonalityGermany |
| spellingShingle | Daniel Allermann Hitz Friedemann Tewald Maren Eggers Seasonal Bordetella pertussis pattern in the period from 2008 to 2018 in Germany BMC Infectious Diseases Pertussis Whooping cough Seasonality Germany |
| title | Seasonal Bordetella pertussis pattern in the period from 2008 to 2018 in Germany |
| title_full | Seasonal Bordetella pertussis pattern in the period from 2008 to 2018 in Germany |
| title_fullStr | Seasonal Bordetella pertussis pattern in the period from 2008 to 2018 in Germany |
| title_full_unstemmed | Seasonal Bordetella pertussis pattern in the period from 2008 to 2018 in Germany |
| title_short | Seasonal Bordetella pertussis pattern in the period from 2008 to 2018 in Germany |
| title_sort | seasonal bordetella pertussis pattern in the period from 2008 to 2018 in germany |
| topic | Pertussis Whooping cough Seasonality Germany |
| url | http://link.springer.com/article/10.1186/s12879-020-05199-w |
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