TDG is a novel tumor suppressor of liver malignancies
In a recent publication, we demonstrated that conditional deletion of the gene encoding thymine DNA glycosylase (TDG) leads to a late onset of hepatocellular carcinoma (HCC). TDG loss causes disruption in active DNA demethylation in the liver and dysregulation of the farnesoid X receptor and small h...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1768819 |
| _version_ | 1827809333910437888 |
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| author | Haider M. Hassan Majdina Isovic Michael Tully Underhill Joseph Torchia |
| author_facet | Haider M. Hassan Majdina Isovic Michael Tully Underhill Joseph Torchia |
| author_sort | Haider M. Hassan |
| collection | DOAJ |
| description | In a recent publication, we demonstrated that conditional deletion of the gene encoding thymine DNA glycosylase (TDG) leads to a late onset of hepatocellular carcinoma (HCC). TDG loss causes disruption in active DNA demethylation in the liver and dysregulation of the farnesoid X receptor and small heterodimer partner (FXR-SHP) regulatory cascade. This leads to a loss of bile acid and glucose homeostasis, which predisposes mice to HCC. |
| first_indexed | 2024-03-11T22:39:43Z |
| format | Article |
| id | doaj.art-493b13ea6e5e40bcace86ea9279e097e |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:43Z |
| publishDate | 2020-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-493b13ea6e5e40bcace86ea9279e097e2023-09-22T09:11:02ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-07-017410.1080/23723556.2020.17688191768819TDG is a novel tumor suppressor of liver malignanciesHaider M. Hassan0Majdina Isovic1Michael Tully Underhill2Joseph Torchia3Western UniversityWestern UniversityUniversity of British ColumbiaWestern UniversityIn a recent publication, we demonstrated that conditional deletion of the gene encoding thymine DNA glycosylase (TDG) leads to a late onset of hepatocellular carcinoma (HCC). TDG loss causes disruption in active DNA demethylation in the liver and dysregulation of the farnesoid X receptor and small heterodimer partner (FXR-SHP) regulatory cascade. This leads to a loss of bile acid and glucose homeostasis, which predisposes mice to HCC.http://dx.doi.org/10.1080/23723556.2020.1768819thymine dna glycosylaseten eleven translocationfxrbile acidglucose intoleranceliver cancerhepatocellular carcinomaactive dna demethylationshp |
| spellingShingle | Haider M. Hassan Majdina Isovic Michael Tully Underhill Joseph Torchia TDG is a novel tumor suppressor of liver malignancies Molecular & Cellular Oncology thymine dna glycosylase ten eleven translocation fxr bile acid glucose intolerance liver cancer hepatocellular carcinoma active dna demethylation shp |
| title | TDG is a novel tumor suppressor of liver malignancies |
| title_full | TDG is a novel tumor suppressor of liver malignancies |
| title_fullStr | TDG is a novel tumor suppressor of liver malignancies |
| title_full_unstemmed | TDG is a novel tumor suppressor of liver malignancies |
| title_short | TDG is a novel tumor suppressor of liver malignancies |
| title_sort | tdg is a novel tumor suppressor of liver malignancies |
| topic | thymine dna glycosylase ten eleven translocation fxr bile acid glucose intolerance liver cancer hepatocellular carcinoma active dna demethylation shp |
| url | http://dx.doi.org/10.1080/23723556.2020.1768819 |
| work_keys_str_mv | AT haidermhassan tdgisanoveltumorsuppressoroflivermalignancies AT majdinaisovic tdgisanoveltumorsuppressoroflivermalignancies AT michaeltullyunderhill tdgisanoveltumorsuppressoroflivermalignancies AT josephtorchia tdgisanoveltumorsuppressoroflivermalignancies |